嗅神经母细胞瘤复发表现为抗利尿激素分泌异常综合征。

Esthesioneuroblastoma recurrence presenting as a syndrome of inappropriate antidiuretic hormone secretion.

作者信息

Plasencia Y López, Cortés M Boronat, Arencibia D Marrero, Dámaso T Montenegro, Contreras I Lisner, Pino A Ojeda, Domínguez A Carrillo, Brier F La Roche, Delgado Y García, Mogollón F J Nóvoa

机构信息

Endocrinology Department, Hospital Universitario Insular de Gran Canaria, Las Palmas de Gran Canaria University, Avda. Marítima del Sur s/n, 35016. Las Palmas de Gran Canaria, Spain.

出版信息

Head Neck. 2006 Dec;28(12):1142-6. doi: 10.1002/hed.20352.

DOI:10.1002/hed.20352

PMID:16721738

Abstract

BACKGROUND

Esthesioneuroblastoma is an uncommon intranasal tumor. These neuroendocrine neoplasms are rarely associated with excess hormone syndromes, and only nine cases of inappropriate antidiuretic hormone syndrome (SIADH) secondary to an esthesioneuroblastoma have been described. In all these cases, electrolyte abnormalities were seen when the tumor initially developed. We report a unique case of esthesioneuroblastoma recurrence manifesting as SIADH as the solely presenting feature.

METHODS AND RESULTS

A 34-year-old woman was referred to us for evaluation for hyponatremia. She had undergone resection of an esthesioneuroblastoma at age 18 with radiotherapy. The patient had undergone annual CT of the nasal area and was considered to be disease free. The study of the hyponatremia was consistent with a SIADH, and MRI revealed an intranasal mass. The resection of the tumor reversed the hyponatremia, and pathologic analysis revealed a recurrence of esthesioneuroblastoma.

CONCLUSIONS

Biochemical analysis should be performed in the follow-up of patients with esthesioneuroblastoma. In our case, the biochemical abnormality led to the diagnosis of the recurrence.

摘要