Fosbøl Marie Øbro, Bilde Anders, Friborg Jeppe, von Benzon Eric, Kjær Andreas, von Buchwald Christian, Borgwardt Lise
Department of Clinical Physiology, Nuclear Medicine & PET, Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, DK-2100 Copenhagen, Denmark.
Department of ORL, Head & Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, DK-2100 Copenhagen, Denmark.
Diagnostics (Basel). 2018 Jan 14;8(1):8. doi: 10.3390/diagnostics8010008.
Esthesioneuroblastoma (ENB) is an uncommon neuroendocrine tumor originating from the olfactory neuroepithelium and accounts for 3-6% of all intranasal tumors [¹]. ENBs can be locally aggressive and cause invasion and destruction of surrounding structures. Histological grading and clinical stage at presentation are highly predictive of survival and especially presence of lymph node and distant metastases are determining prognostic factors [²,³,⁴,⁵]. Thus, reliable imaging is essential in these patients. Conventional imaging modalities for staging ENB are magnetic resonance imaging (MRI) and computed tomography (CT). However, fluorine-18 fluoro-2-deoxy-d-glucose positron emission tomography/CT (F-FDG PET/CT) has been reported as a valuable adjunct and was found to upstage 36% of ENB patients compared to conventional imaging [6]. We present a case demonstrating the diagnostic work-up and follow-up with F-FDG PET/CT in a young patient with ENB with a highly atypical clinical presentation.
嗅神经母细胞瘤（ENB）是一种罕见的神经内分泌肿瘤，起源于嗅神经上皮，占所有鼻内肿瘤的3% - 6%[1]。ENB具有局部侵袭性，可导致周围结构的侵犯和破坏。就诊时的组织学分级和临床分期对生存具有高度预测性，尤其是淋巴结和远处转移的存在是决定预后的因素[2,3,4,5]。因此，可靠的影像学检查对这些患者至关重要。用于ENB分期的传统影像学检查方法是磁共振成像（MRI）和计算机断层扫描（CT）。然而，氟-18氟-2-脱氧-D-葡萄糖正电子发射断层扫描/计算机断层扫描（F-FDG PET/CT）已被报道为一种有价值的辅助检查，与传统影像学相比，发现它能使36%的ENB患者分期上调[6]。我们报告一例年轻ENB患者，其临床表现高度不典型，展示了F-FDG PET/CT在诊断检查和随访中的应用。
