Parrilla C, Lucidi D, Petrone G, Bastanza G, Colosimo C
Institute of Otolaryngology Catholic university of Sacred Heart, Rome, Italy.
Institute of Pathological Anatomy and Cytopathology, Catholic University of Sacred Heart, Rome, Italy.
Acta Otorhinolaryngol Ital. 2017 Feb;37(1):76-79. doi: 10.14639/0392-100X-1141.
Olfactory neuroblastoma (ONB) is an uncommon neuroendocrine sinonasal cancer associated by many authors to ectopic production of several biologically active substances. We report a case of a 31-year-old male patient who presented with idiopathic syndrome of inappropriate secretion of antidiuretic hormone (SIADH). During diagnostic work-up, a CT scan of the head was performed and an ethmoidal ONB was detected. Endoscopical surgery followed by radiotherapy was carried out. Immediately after surgery natraemia levels normalised. Five years later the patient is disease-free. To our knowledge, 17 cases of SIADH associated to ONB have been published. In nine reports, idiopathic SIADH promptly led to the diagnosis of the sinonasal mass as in our clinical case, however, in many reports, correct diagnosis was accomplished months to years later. In young patients with idiopathic inappropriate antidiuretic hormone secretion, a neuroendocrine malignancy of the sinonasal area must be excluded.
嗅神经母细胞瘤（ONB）是一种罕见的神经内分泌性鼻窦癌，许多作者认为它与多种生物活性物质的异位产生有关。我们报告一例31岁男性患者，其表现为抗利尿激素不适当分泌综合征（SIADH）。在诊断检查过程中，进行了头部CT扫描，发现了筛窦ONB。随后进行了内镜手术及放疗。术后血钠水平立即恢复正常。五年后患者无病生存。据我们所知，已发表了17例与ONB相关的SIADH病例。在9篇报告中，特发性SIADH迅速导致鼻窦肿物的诊断，如同我们的临床病例，但在许多报告中，正确诊断是在数月至数年之后才完成的。对于特发性抗利尿激素分泌不适当的年轻患者，必须排除鼻窦区域的神经内分泌恶性肿瘤。
