Lu Shi-Long, Herrington Heather, Wang Xiao-Jing
Department of Otolaryngology, Oregon Health & Science University, PVMC Building 103-F221, R&D 46, 3710 SW US Veterans Hospital Road, Portland, OR 97239, USA.
Head Neck. 2006 Oct;28(10):945-54. doi: 10.1002/hed.20397.
Mouse models of human cancer play an important role in understanding the mechanisms of carcinogenesis and have accelerated the search for finding new molecular targets for cancer therapy. However, genetically engineered mouse models for head and neck squamous cell carcinoma (HNSCC) have only recently overcome major technical obstacles and begun to be explored. Here we review the current progress in the development of mouse models for human HNSCC, with emphasis on conditional transgenic and knockout mouse models. These new models faithfully recapitulate human HNSCC at both the pathologic and molecular levels. These animal models will not only be useful to define the roles of specific genes in HNSCC development and progression but will also provide a unique tool for developing and testing new therapeutic approaches.
人类癌症的小鼠模型在理解致癌机制方面发挥着重要作用，并加速了寻找癌症治疗新分子靶点的进程。然而，头颈部鳞状细胞癌（HNSCC）的基因工程小鼠模型直到最近才克服了主要技术障碍并开始得到探索。在此，我们综述了人类HNSCC小鼠模型开发的当前进展，重点关注条件性转基因和基因敲除小鼠模型。这些新模型在病理和分子水平上都能忠实地重现人类HNSCC。这些动物模型不仅有助于确定特定基因在HNSCC发生和发展中的作用，还将为开发和测试新的治疗方法提供一个独特的工具。
