Lei Zhen-Ge, Ren Xiao-Hua, Wang Sha-Sha, Liang Xin-Hua, Tang Ya-Ling
Department of Oral and Maxillofacial Surgery, Stomatological Hospital Affiliated to Nanchang University, Nanchang, Jiangxi, People's Republic of China.
Department of Stomatology, Sichuan Medical Science Academy and Sichuan Provincial People's Hospital, Chengdu, Sichuan, People's Republic of China.
Onco Targets Ther. 2016 Jan 27;9:545-55. doi: 10.2147/OTT.S95633. eCollection 2016.
Mouse models can closely mimic human oral squamous epithelial carcinogenesis, greatly expand the in vivo research possibilities, and play a critical role in the development of diagnosis, monitoring, and treatment of head and neck squamous cell carcinoma. With the development of the recent research on the contribution of immunity/inflammation to cancer initiation and progression, mouse models have been divided into two categories, namely, immunocompromised and immunocompetent mouse models. And thus, this paper will review these two kinds of models applied in head and neck squamous cell carcinoma to provide a platform to understand the complicated histological, molecular, and genetic changes of oral squamous epithelial tumorigenesis.
小鼠模型能够紧密模拟人类口腔鳞状上皮癌发生过程，极大地拓展体内研究的可能性，并在头颈部鳞状细胞癌的诊断、监测及治疗发展中发挥关键作用。随着近期关于免疫/炎症在癌症发生和进展中的作用的研究不断发展，小鼠模型已被分为两类，即免疫缺陷小鼠模型和免疫健全小鼠模型。因此，本文将综述这两类应用于头颈部鳞状细胞癌的模型，以提供一个平台来了解口腔鳞状上皮肿瘤发生过程中复杂的组织学、分子和遗传学变化。
