Vandenberg R J
Department of Pharmacology, Institute for Biomedical Research, University of Sydney, 2006 New South Wales, Australia.
Handb Exp Pharmacol. 2006(175):113-35. doi: 10.1007/3-540-29784-7_6.
Glutamate transporters are a family of transporters that regulate extracellular glutamate concentrations so as to maintain a dynamic and high-fidelity cell signalling process in the brain. Site-directed mutagenesis has been used to investigate various aspects of the structural and functional properties of these transporters to gain insights into how they work. This field of research has recently undergone a major development with the determination of the crystal structure of a bacterial glutamate transporter, and this chapter relates the results from mutagenesis experiments with what we now know about glutamate transporter structure.
谷氨酸转运体是一类调节细胞外谷氨酸浓度的转运体家族，以便在大脑中维持动态且高保真的细胞信号传导过程。定点诱变已被用于研究这些转运体结构和功能特性的各个方面，以深入了解它们的工作方式。随着一种细菌谷氨酸转运体晶体结构的确定，该研究领域最近取得了重大进展，本章将诱变实验的结果与我们目前对谷氨酸转运体结构的了解联系起来。
