共济失调毛细血管扩张症互补组C（ATC）基因座定位于11号染色体长臂22区至23区。
The ATC (ataxia-telangiectasia complementation group C) locus localizes to 11q22-q23.
作者信息
Ziv Y, Rotman G, Frydman M, Dagan J, Cohen T, Foroud T, Gatti R A, Shiloh Y
机构信息
Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Israel.
出版信息
Genomics. 1991 Feb;9(2):373-5. doi: 10.1016/0888-7543(91)90268-j.
The multisystem autosomal recessive disease ataxia-telangiectasia (A-T) is determined by several genes, as evidenced by the existence of four complementation groups in this disorder. Using linkage analysis, the ATA (A-T complementation group A) gene was previously localized to chromosome 11, region q22-q23. Analysis of the segregation of RFLP markers from this region in a Jewish-Moroccan family assigned to group C indicates that the ATC (A-T complementation group C) gene localizes to chromosome 11q22-q23 as well.
多系统常染色体隐性疾病共济失调毛细血管扩张症（A-T）由多个基因决定，该疾病中存在四个互补组就证明了这一点。通过连锁分析，ATA（A-T互补组A）基因先前被定位到11号染色体q22-q23区域。对一个被归为C组的犹太-摩洛哥家族中该区域RFLP标记的分离分析表明，ATC（A-T互补组C）基因也定位于11号染色体q22-q23区域。
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