小鼠第16号染色体的多点基因定位

The multipoint genetic mapping of mouse chromosome 16.

作者信息

Irving N G, Hardy J A, Brown S D

机构信息

Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, London, United Kingdom.

出版信息

Genomics. 1991 Feb;9(2):386-9. doi: 10.1016/0888-7543(91)90271-f.

DOI:10.1016/0888-7543(91)90271-f

PMID:1672298

Abstract

Utilizing a Mus spretus/Mus domesticus (C57BL/10) interspecific backcross, we have constructed a multipoint genetic map of mouse chromosome 16 that extends 43.2 cM from the proximal Prm-1 locus to the distal Ets-2 locus. The genetic map incorporates three new markers: D16Smh6, a random genomic clone; Pgk-1ps1, a phosphoglycerate kinase pseudogene; and the growth-associated protein Gap43. The map position of Gap43 indicates the presence, on mouse chromosome 16, of a significant-size conserved linkage group with human chromosome 3.

摘要

利用小家鼠/家鼠（C57BL/10）种间回交，我们构建了小鼠16号染色体的多点遗传图谱，该图谱从近端的Prm-1基因座延伸至远端的Ets-2基因座，长度为43.2厘摩。该遗传图谱纳入了三个新标记：随机基因组克隆D16Smh6、磷酸甘油酸激酶假基因Pgk-1ps1以及生长相关蛋白Gap43。Gap43的图谱位置表明，在小鼠16号染色体上存在一个与人类3号染色体具有显著大小的保守连锁群。