Li Shao-Hong, Cai Shao-Xi, Liu Bing, Ma Kai-Wang, Wang Zhen-Ping, Li Xiao-Kun
Key Laboratory for Biomechanical and Tissue Engineering, State Ministry of Education, College of Bioengineerin, Chongqing University, Chongqing 400030, China.
Acta Pharmacol Sin. 2006 Jun;27(6):754-9. doi: 10.1111/j.1745-7254.2006.00337.x.
To construct a sustained drug release system for basic fibroblast growth factor (bFGF). With this special system, bFGF can be used to repair an injured peripheral nerve, injured spinal cord, or as a carrier for other drugs that need to be released over a long time.
Microsphere composite was prepared by encapsulating bFGF into gelatin particles with poly(lactic-co-glycolic acid) (PLGA) as its outer-coating. The encapsulation was conducted by a phase separation method.
The average diameter of the gelatin particle-PLGA microsphere composite was 5-18 mum, and bFGF-loading efficiency was up to 80.5%. The bFGF releasing experiment indicated that this new composite system could release bFGF continuously and protect bFGF from denaturation.
A modified approach was successfully employed to develop a biodegradable system for sustained release of the drug of bFGF in vitro.
构建碱性成纤维细胞生长因子（bFGF）的缓释系统。借助该特殊系统，bFGF可用于修复受损的周围神经、脊髓，或作为其他需要长时间释放的药物的载体。
通过将bFGF包裹于明胶颗粒中，并以聚乳酸-羟基乙酸共聚物（PLGA）作为外层包衣来制备微球复合物。包封采用相分离法进行。
明胶颗粒-PLGA微球复合物的平均直径为5-18微米，bFGF的载药效率高达80.5%。bFGF释放实验表明，这种新型复合系统能够持续释放bFGF，并保护bFGF不发生变性。
成功采用一种改良方法开发出一种可生物降解的系统，用于在体外持续释放bFGF药物。
