Calvo M I
Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, University of Navarra, C/Irularrea s/n, 31008, Pamplona Spain.
J Ethnopharmacol. 2006 Oct 11;107(3):380-2. doi: 10.1016/j.jep.2006.03.037. Epub 2006 Apr 18.
Verbena officinalis has traditionally been used in herbal medicine in Navarra, Spain, in the treatment of topical inflammation. Due to the anti-inflammatory activity of Verbena officinalis 50% methanolic extract in i.p. and topical administration, the effects of several formulations were prepared and studied using carrageenan-induced edema and formalin testing. Piroxicam gel and methyl salicylate ointment were studied as positive control for anti-inflammatory and analgesic activity, respectively. The edema inhibition of the preparations containing extract at the doses of 1-3% w/w were significantly different from the control group. The anti-inflammatory effect of VO-3% was similar to the effect of piroxicam gel 3 h after carrageenan injection. The analgesic activity of topical preparation with more than 2.5% w/w was observed in the early phase. This activity was observed in concentrations of more than 2% w/w in the late phase. The topical analgesic activity of the extract was less than the analgesic activity of methyl salicylate ointment.
在西班牙纳瓦拉，马鞭草传统上被用于草药医学中治疗局部炎症。由于马鞭草50%甲醇提取物经腹腔注射和局部给药具有抗炎活性，因此制备了几种制剂，并使用角叉菜胶诱导的水肿和福尔马林试验进行了研究。分别以吡罗昔康凝胶和水杨酸甲酯软膏作为抗炎和镇痛活性的阳性对照。含1-3%w/w提取物的制剂对水肿的抑制作用与对照组有显著差异。注射角叉菜胶3小时后，3%的马鞭草提取物的抗炎效果与吡罗昔康凝胶相似。在早期观察到含药量超过2.5%w/w的局部制剂具有镇痛活性。在后期，当浓度超过2%w/w时可观察到这种活性。提取物的局部镇痛活性低于水杨酸甲酯软膏的镇痛活性。
