马鞭草通过抑制ROS-ERK1/2-NLRP3信号通路减轻阿霉素诱导的肾小管损伤。
Verbena Attenuates Adriamycin-Induced Renal Tubular Injury via Inhibition of ROS-ERK1/2-NLRP3 Signal Pathway.
作者信息
Zhou Yicen, Wu Qijing, Du Zhenfang, Huang Min, Gao Kun, Ma Xiaowei, Zhang Hui, Qiang Sheng, Sun Wei
机构信息
Department of Nephropathy, Center Laboratory, Zhangjiagang Traditional Chinese Medicine Hospital, Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang 215600, Jiangsu, China.
Department of Traditional Chinese Medicine, Huai'an First People's Hospital, Nanjing Medical University, Huai'an 223399, Jiangsu, China.
出版信息
Evid Based Complement Alternat Med. 2022 Sep 28;2022:7760945. doi: 10.1155/2022/7760945. eCollection 2022.
Chronic kidney disease (CKD) has become a global public health problem. Tubular epithelial cell injury plays a vital role in the progression and prognosis of CKD. Therapies to protect tubular cells is the key to delaying CKD progression. Our study found that verbena, a natural traditional Chinese herb, has a potential reno-protective role in kidney diseases. However, the detailed mechanism remains unknown. In the current study, we employed adriamycin (ADR)-induced renal tubular cell injury to mimic the conditions of tubular injury in vitro. Results showed that total aqueous exact of verbena (TAEV) ameliorated ADR-induced cell disruption, loss of cellular viability, and apoptosis via inhibition of ROS-ERK1/2-mediated activation of NLRP3 signal pathway, suggesting that TAEV serves as a promising renoprotective agent in delaying the progression of CKD, while ROS-ERK1/2-mediated NLRP3 signal pathway might be a novel target in treating kidney diseases.
慢性肾脏病（CKD）已成为一个全球性的公共卫生问题。肾小管上皮细胞损伤在CKD的进展和预后中起着至关重要的作用。保护肾小管细胞的治疗方法是延缓CKD进展的关键。我们的研究发现，马鞭草，一种天然的传统中药，在肾脏疾病中具有潜在的肾脏保护作用。然而，具体机制仍不清楚。在本研究中，我们采用阿霉素（ADR）诱导的肾小管细胞损伤来模拟体外肾小管损伤的情况。结果表明，马鞭草总水提取物（TAEV）通过抑制ROS-ERK1/2介导的NLRP3信号通路激活，改善了ADR诱导的细胞破坏、细胞活力丧失和细胞凋亡，表明TAEV在延缓CKD进展方面是一种有前景的肾脏保护剂，而ROS-ERK1/2介导的NLRP3信号通路可能是治疗肾脏疾病的一个新靶点。
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