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帕金森病中的记忆缺陷。

Memory deficits in Parkinson's disease.

作者信息

Whittington Craig J, Podd John, Stewart-Williams Steve

机构信息

Sub-Department of Clinical Health Psychology, University College London, London.

出版信息

J Clin Exp Neuropsychol. 2006 Jul;28(5):738-54. doi: 10.1080/13803390590954236.

Abstract

The purpose of this study was to investigate deficits in recognition, recall, and prospective memory among Parkinson's disease (PD) patients, and to ascertain whether task difficulty and disease severity moderate these deficits. Comparisons were made between 41 nondemented PD participants, divided into early-stage and advanced-stage groups, and 41 matched controls. PD participants exhibited deficits in recognition, recall, and prospective memory. The advanced-stage PD group produced greater deficits than the early-stage PD group in all tasks, suggesting that these deficits increase in step with overall disease severity. The results of the task difficulty manipulation provide a partial explanation for the inconsistencies in the literature concerning the existence of recognition memory deficits in PD.

摘要

本研究的目的是调查帕金森病(PD)患者在识别、回忆和前瞻性记忆方面的缺陷,并确定任务难度和疾病严重程度是否会缓和这些缺陷。对41名非痴呆型PD参与者(分为早期组和晚期组)和41名匹配的对照组进行了比较。PD参与者在识别、回忆和前瞻性记忆方面表现出缺陷。晚期PD组在所有任务中产生的缺陷比早期PD组更大,这表明这些缺陷随着疾病总体严重程度的增加而增加。任务难度操纵的结果为文献中关于PD患者识别记忆缺陷存在的不一致性提供了部分解释。

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