孔蛋白和质粒介导的AmpCβ-内酰胺酶对肺炎克雷伯菌所致大鼠肺炎中β-内酰胺类药物疗效的影响。
Effect of porins and plasmid-mediated AmpC beta-lactamases on the efficacy of beta-lactams in rat pneumonia caused by Klebsiella pneumoniae.
作者信息
Padilla Emma, Alonso Diana, Doménech-Sánchez Antonio, Gomez Cristina, Pérez José Luis, Albertí Sebastián, Borrell Nuria
机构信息
Servicio de Microbiología, Hospital Son Dureta, IUNICS, Palma de Mallorca, Spain.
出版信息
Antimicrob Agents Chemother. 2006 Jun;50(6):2258-60. doi: 10.1128/AAC.01513-05.
Abstract
The in vivo activities of imipenem, meropenem, and cefepime were studied in a model of rat pneumonia caused by a plasmid-mediated AmpC beta-lactamase ACT-1-producing Klebsiella pneumoniae strain (K. pneumoniae strain 12) and a derivative porin-deficient mutant (K. pneumoniae strain 12dp). No differences between these activities were seen with K. pneumoniae 12. Only meropenem showed an activity slightly better than that of imipenem with K. pneumoniae 12dp.
摘要
在由产质粒介导的AmpCβ-内酰胺酶ACT-1的肺炎克雷伯菌菌株（肺炎克雷伯菌菌株12）和衍生的孔蛋白缺陷突变体（肺炎克雷伯菌菌株12dp）引起的大鼠肺炎模型中，研究了亚胺培南、美罗培南和头孢吡肟的体内活性。肺炎克雷伯菌12在这些活性之间未观察到差异。对于肺炎克雷伯菌12dp，只有美罗培南显示出略优于亚胺培南的活性。
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