产超广谱β-内酰胺酶肺炎克雷伯菌和大肠埃希菌对亚胺培南或美罗培南耐药的流行率及其影响因素。
Prevalence and contributing factors of nonsusceptibility to imipenem or meropenem in extended-spectrum β-lactamase-producing Klebsiella pneumoniae and Escherichia coli.
机构信息
Department of Laboratory Medicine, School of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-ku, Seoul, 137-701, South Korea.
出版信息
Diagn Microbiol Infect Dis. 2011 Sep;71(1):87-9. doi: 10.1016/j.diagmicrobio.2010.12.012. Epub 2011 Mar 11.
Among the extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae and Escherichia coli, 3.9% of K. pneumoniae showed nonsusceptibility to imipenem or meropenem; and their mechanism was the combination of ESBL and/or plasmid-mediated AmpC β-lactamase production and porin loss. The presence of bla(CTX-M-14) and loss of OmpK36 were associated with higher carbapenem MICs.
在产超广谱β-内酰胺酶（ESBL）的肺炎克雷伯菌和大肠埃希菌中，3.9%的肺炎克雷伯菌对亚胺培南或美罗培南表现出耐药性；其机制是 ESBL 和/或质粒介导的 AmpC β-内酰胺酶产生以及孔蛋白缺失的组合。bla(CTX-M-14)的存在和 OmpK36 的缺失与更高的碳青霉烯类 MIC 相关。
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