Green M H, Arlett C F, Cole J, Harcourt S A, Priestley A, Waugh A P, Stephens G, Beare D M, Brown N A, Shun-Shin G A
MRC Cell Mutation Unit, Sussex University, Brighton, UK.
Int J Radiat Biol. 1991 Mar;59(3):749-65. doi: 10.1080/09553009114550661.
Skin and blood samples were obtained from 34 donors, for whom there was no indication of abnormal radiosensitivity. From these, in 33 cases both fibroblast and T-lymphocyte cultures were obtained and in 26 cases at least three fibroblast and at least two G0 (resting) T-lymphocyte survival assays were possible. Within this set of results, differences in radiosensitivity between donors were significant for fibroblasts but not T-lymphocytes, although the range of radiosensitivity was similar for the two cell types (D 0.90-1.68 Gy for fibroblasts; 1.26-2.15 Gy for T-lymphocytes). Furthermore, there was little evidence for a correlation in radiosensitivity between the two cell types. These results suggest limitations in the predictive value of conventional measurement of cell survival.
