Waugh A P, Beare D M, Arlett C F, Green M H, Cole J
MRC Cell Mutation Unit, University of Sussex, Falmer, Brighton, UK.
Int J Radiat Biol. 1991 Mar;59(3):767-76. doi: 10.1080/09553009114550671.
We have compared the gamma-irradiation survival of G0 peripheral blood lymphocytes from 18 neonatal cord blood samples in a cloning assay with results from 21 controls (age range 1-65 years and consisting of 20 adults and one child). Using mean inactivation dose as the discriminating parameter, the cord blood cells showed a significantly greater radiosensitivity (mean inactivation dose for pooled data = 1.54 Gy) than the normal controls (mean inactivation dose for pooled data = 1.90 Gy, p less than 0.001). These results confirm and extend earlier work suggesting that T-lymphocytes in newborn children are more radiosensitive than normal controls, and this may have implications for the radiation protection of the unborn child.
我们在一项克隆试验中比较了18份新生儿脐带血样本中处于G0期的外周血淋巴细胞经γ射线照射后的存活率，并与21名对照者（年龄范围为1至65岁，包括20名成年人和1名儿童）的结果进行了对比。以平均失活剂量作为判别参数，脐带血细胞显示出比正常对照者显著更高的放射敏感性（合并数据的平均失活剂量 = 1.54 Gy），而正常对照者的平均失活剂量为1.90 Gy（p < 0.001）。这些结果证实并拓展了早期的研究工作，表明新生儿的T淋巴细胞比正常对照者对辐射更敏感，这可能对未出生胎儿的辐射防护具有重要意义。
