质谱分析中的衍生化——8. 小分子的软电离质谱分析
Derivatization in mass spectrometry--8. Soft ionization mass spectrometry of small molecules.
作者信息
Zaikin Vladimir G, Halket John M
机构信息
Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Leninsky prospect 29, 119991Moscow, Russia.
出版信息
Eur J Mass Spectrom (Chichester). 2006;12(2):79-115. doi: 10.1255/ejms.798.
DOI:10.1255/ejms.798
PMID:16723751
Abstract
This is the first of two reviews devoted to derivatization approaches for "soft" ionization mass spectrometry (FAB, MALDI, ESI, APCI) and deals, in particular, with small molecules. The principles of the main "soft" ionization mass spectrometric methods as well as the reasons for derivatizing small molecules are briefly described. Derivatization methods for modification of amines, carboxylic acids, amino acids, alcohols, carbonyl compounds, monosaccharides, thiols, unsaturated and aromatic compounds etc. to improve their ionizability and to enhance structure information content are discussed. The use of "fixed"-charge bearing derivatization reagents is especially emphasized. Chemical aspects of derivatization and "soft" ionization mass spectrometric properties of derivatives are considered.
摘要
这是两篇关于“软”电离质谱（FAB、MALDI、ESI、APCI）衍生化方法的综述中的第一篇，尤其涉及小分子。简要描述了主要“软”电离质谱方法的原理以及小分子衍生化的原因。讨论了用于修饰胺、羧酸、氨基酸、醇、羰基化合物、单糖、硫醇、不饱和及芳香族化合物等的衍生化方法，以提高其离子化能力并增强结构信息含量。特别强调了使用带有“固定”电荷的衍生化试剂。考虑了衍生化的化学方面以及衍生物的“软”电离质谱性质。
相似文献
1
Derivatization in mass spectrometry--8. Soft ionization mass spectrometry of small molecules.质谱分析中的衍生化——8. 小分子的软电离质谱分析
Eur J Mass Spectrom (Chichester). 2006;12(2):79-115. doi: 10.1255/ejms.798.
2
Charge derivatization of peptides for analysis by mass spectrometry.用于质谱分析的肽的电荷衍生化
Mass Spectrom Rev. 1998 Jul-Aug;17(4):255-74. doi: 10.1002/(SICI)1098-2787(1998)17:4<255::AID-MAS1>3.0.CO;2-4.
3
A new strategy for ionization enhancement by derivatization for mass spectrometry.一种通过衍生化提高质谱电离效率的新策略。
J Chromatogr B Analyt Technol Biomed Life Sci. 2011 May 15;879(17-18):1159-65. doi: 10.1016/j.jchromb.2011.02.008. Epub 2011 Feb 13.
4
Sensitivity enhancement in liquid chromatography/atmospheric pressure ionization mass spectrometry using derivatization and mobile phase additives.使用衍生化和流动相添加剂提高液相色谱/大气压电离质谱的灵敏度
J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Oct 25;825(2):98-110. doi: 10.1016/j.jchromb.2005.04.021.
5
FAB, ESI and MALDI Mass Spectrometric methods in the study of metallo-drugs and their biomolecular interactions.FAB、ESI 和 MALDI 质谱方法在金属药物及其生物分子相互作用研究中的应用。
Metallomics. 2011 Jun;3(6):550-65. doi: 10.1039/c0mt00096e. Epub 2011 Apr 11.
6
Characterization of carbohydrates using a combination of derivatization, high-performance liquid chromatography and mass spectrometry.采用衍生化、高效液相色谱和质谱联用技术对碳水化合物进行表征。
J Chromatogr A. 1998 Jun 19;811(1-2):47-59. doi: 10.1016/s0021-9673(98)00238-6.
7
Derivatization of small biomolecules for optimized matrix-assisted laser desorption/ionization mass spectrometry.用于优化基质辅助激光解吸/电离质谱分析的小分子生物分子衍生化
J Mass Spectrom. 2002 Sep;37(9):963-73. doi: 10.1002/jms.355.
8
Fast atom bombardment mass spectrometric characterization of peptides.肽的快原子轰击质谱表征
Mol Biotechnol. 1998 Apr;9(2):141-54. doi: 10.1007/BF02760815.
9
Characterization of gallotannins from Astronium species by flow injection analysis- electrospray ionization-ion trap-tandem mass spectrometry and matrix-assisted laser desorption/ionization time-of- flight mass spectrometry.通过流动注射分析-电喷雾电离-离子阱串联质谱法和基质辅助激光解吸/电离飞行时间质谱法对沙箱树属植物中的没食子单宁进行表征
Eur J Mass Spectrom (Chichester). 2011;17(4):365-75. doi: 10.1255/ejms.1141.
10
Isothiocyanates as derivatization reagents for amines in liquid chromatography/electrospray ionization-tandem mass spectrometry.异硫氰酸酯作为液相色谱/电喷雾电离串联质谱中胺类的衍生化试剂。
Biomed Chromatogr. 2010 Sep;24(9):915-8. doi: 10.1002/bmc.1352.
引用本文的文献
1
Reactivity-based identification of oxygen containing functional groups of chemicals applied as potential classifier in non-target analysis.基于反应性的化学品含氧官能团鉴定在非靶标分析中用作潜在分类器。
Sci Rep. 2023 Dec 20;13(1):22828. doi: 10.1038/s41598-023-50240-y.
2
Facile and versatile ligand analysis method of colloidal quantum dot.胶体量子点简便通用的配体分析方法
Sci Rep. 2021 Oct 6;11(1):19889. doi: 10.1038/s41598-021-99358-x.
3
Direct Liquid Extraction and Ionization Techniques for Understanding Multimolecular Environments in Biological Systems (Secondary Publication).用于理解生物系统中多分子环境的直接液体萃取和电离技术（二次发表）
Mass Spectrom (Tokyo). 2021;10(1):A0095. doi: 10.5702/massspectrometry.A0095. Epub 2021 Jun 30.
4
On-tissue chemical derivatization in mass spectrometry imaging.组织内化学衍生化在质谱成像中的应用。
Mass Spectrom Rev. 2022 Sep;41(5):662-694. doi: 10.1002/mas.21680. Epub 2021 Jan 12.
5
Recent developments of novel matrices and on-tissue chemical derivatization reagents for MALDI-MSI.新型基质和组织内化学衍生试剂在 MALDI-MSI 中的最新进展。
Anal Bioanal Chem. 2021 Apr;413(10):2599-2617. doi: 10.1007/s00216-020-03023-7. Epub 2020 Nov 19.
6
Untargeted lipidomic analysis of human tears: A new approach for quantification of O-acyl-omega hydroxy fatty acids.非靶向脂质组学分析人眼泪：定量分析 O-酰基-ω-羟基脂肪酸的新方法。
Ocul Surf. 2019 Apr;17(2):347-355. doi: 10.1016/j.jtos.2019.02.004. Epub 2019 Feb 25.
7
Urinary Metabolomics Study of Patients with Gout Using Gas Chromatography-Mass Spectrometry.基于气相色谱-质谱联用的痛风患者尿液代谢组学研究。
Biomed Res Int. 2018 Oct 16;2018:3461572. doi: 10.1155/2018/3461572. eCollection 2018.
8
Establishment of a Charge Reversal Derivatization Strategy to Improve the Ionization Efficiency of Limaprost and Investigation of the Fragmentation Patterns of Limaprost Derivatives Via Exclusive Neutral Loss and Survival Yield Method.建立电荷反转衍生化策略以提高利马前列素的电离效率，并通过专属中性丢失和存活产率法研究利马前列素衍生物的裂解模式。
J Am Soc Mass Spectrom. 2018 Jul;29(7):1365-1375. doi: 10.1007/s13361-018-1924-z. Epub 2018 Apr 9.
9
Online solid phase extraction liquid chromatography tandem mass spectrometry (SPE-LC-MS/MS) method for the determination of sucralose in reclaimed and drinking waters and its photo degradation in natural waters from South Florida.在线固相萃取液相色谱串联质谱法（SPE-LC-MS/MS）测定再生水和饮用水中的三氯蔗糖及其在南佛罗里达天然水中的光降解
Chem Cent J. 2013 Aug 22;7(1):141. doi: 10.1186/1752-153X-7-141.
10
Quantitative profiling of major neutral lipid classes in human meibum by direct infusion electrospray ionization mass spectrometry.直接进样电喷雾电离质谱法定量分析人睑板腺主要中性脂质。
Invest Ophthalmol Vis Sci. 2013 Aug 23;54(8):5730-53. doi: 10.1167/iovs.12-10317.
Zotero 插件