Jensen Ole N
Protein Research Group, Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230 Odense M, Denmark.
Nat Rev Mol Cell Biol. 2006 Jun;7(6):391-403. doi: 10.1038/nrm1939.
Post-translational modifications define the functional and structural plasticity of proteins in archaea, prokaryotes and eukaryotes. Multi-site protein modification modulates protein activity and macromolecular interactions and is involved in a range of fundamental molecular processes. Combining state-of-the-art technologies in molecular cell biology, protein mass spectrometry and bioinformatics, it is now feasible to discover and study the structural and functional roles of distinct protein post-translational modifications.
翻译后修饰决定了古细菌、原核生物和真核生物中蛋白质的功能和结构可塑性。多位点蛋白质修饰调节蛋白质活性和大分子相互作用，并参与一系列基本分子过程。结合分子细胞生物学、蛋白质质谱和生物信息学等前沿技术，现在已经能够发现和研究不同蛋白质翻译后修饰的结构和功能作用。
