Kumar J Ram, Tewari Mallika, Rai Arundhati, Sinha Rohan, Mohapatra Sadhu C, Shukla Hari S
Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
J Surg Oncol. 2006 Jun 15;93(8):610-4. doi: 10.1002/jso.20526.
Gallbladder cancer (GBC) is a lethal disease with a wide geographical, ethnic, and cultural variation suggesting major environmental influences such as diet and life style factors in the development of disease. An objective assessment of demographic profile and full implication of these features to recognize the population at risk is needed. This study was therefore undertaken to study the demography of GBC in Varanasi.
A retrospective study as a case-control model comprised 328 cases of GBC and 328 controls with gallstone disease (GSD). The relevant demographic data were collected and analyzed for identification of independent significant features and for the risk of GBC based on these features by calculating odds ratio.
GBC predominantly a disease of females belonged to fourth and fifth decade of life. Among 328 cases of GBC only 75 were male and 253 female (M:F = 1:3.37). Majority of GBC patients were above 40 years and multiparous females. Family history of GBC was higher in GBC patients. Majority of GBC patients were of low socioeconomic status and hailed from rural background. This group tends to consume open mustard oil and water from hand pump. This study emphasizes the usefulness of demographic evaluation in diagnosis of GBC and a systematic approach to assessment of demographic features of GBC is recommended.
胆囊癌（GBC）是一种致命疾病，在地理、种族和文化方面存在广泛差异，这表明饮食和生活方式等主要环境因素在该疾病的发展中具有重要影响。需要对人口统计学特征进行客观评估，并充分认识这些特征对识别高危人群的意义。因此，本研究旨在探讨瓦拉纳西地区胆囊癌的人口统计学特征。
采用回顾性病例对照研究模型，纳入328例胆囊癌患者和328例胆结石疾病（GSD）对照者。收集并分析相关人口统计学数据，以确定独立的显著特征，并基于这些特征通过计算比值比来评估胆囊癌的风险。
胆囊癌主要是一种女性疾病，发病年龄集中在第四和第五个十年。在328例胆囊癌患者中，只有75例为男性，253例为女性（男:女 = 1:3.37）。大多数胆囊癌患者年龄在40岁以上，且为多产女性。胆囊癌患者的家族病史较高。大多数胆囊癌患者社会经济地位较低，来自农村背景。这一群体倾向于食用散装芥菜籽油和使用手动泵抽取的水。本研究强调了人口统计学评估在胆囊癌诊断中的有用性，并建议采用系统方法评估胆囊癌的人口统计学特征。
