胆囊癌变中的表观遗传变化。
Epigenetic changes in carcinogenesis of gallbladder.
作者信息
Tewari Mallika, Agarwal Amit, Mishra R R, Meena R N, Shukla Hari S
机构信息
Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221 005 U.P. India.
Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
出版信息
Indian J Surg Oncol. 2013 Dec;4(4):356-61. doi: 10.1007/s13193-013-0240-0. Epub 2013 Apr 4.
Gallbladder cancer (GBC) is a lethal and a common malignancy affecting mostly females. There are restricted high incidence pockets across the world and in northern India highest incidence of GBC is reported from the Gangetic belt. The etiology of this disease remains largely unknown though several risk factors have been stated. The genetic aberrations in GBC involving mutations in tumor suppressor genes and oncogenes have been reported in literature. However, there is scarcity of data regarding epigenetic changes that may also be involved in gallbladder carcinogenesis. This review attempts to summarize our current understanding of the epigenetic changes in GBC.
胆囊癌（GBC）是一种致命的常见恶性肿瘤，主要影响女性。全球范围内该病的高发地区有限，在印度北部，恒河一带报告的胆囊癌发病率最高。尽管已经指出了一些危险因素，但这种疾病的病因在很大程度上仍然未知。文献中已报道胆囊癌中的基因异常涉及肿瘤抑制基因和癌基因的突变。然而，关于可能也参与胆囊癌发生的表观遗传变化的数据却很匮乏。本综述试图总结我们目前对胆囊癌表观遗传变化的理解。
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