Sykes Nigel P
St. Christopher's Hospice, London, United Kingdom.
J Support Oncol. 2006 May;4(5):213-8.
The pathogenesis of the constipation that is commonly experienced by cancer patients, especially those with advanced disease, is the result of multiple influences on the control of intestinal motility and fluid handling. These factors include the direct effects of malignancy on gut structure, paraneoplastic neural impairment, biochemical disturbance, and adverse effects of cancer treatments. In addition, the debility and reduced oral intake associated with cancer also contribute, as, perhaps, might the older age of many cancer patients. A detailed understanding of the mechanisms of constipation, especially in association with illness, is lacking, and most treatments remain nonspecific.
癌症患者，尤其是晚期患者常出现便秘，其发病机制是多种因素对肠道蠕动控制和液体处理产生影响的结果。这些因素包括恶性肿瘤对肠道结构的直接影响、副肿瘤性神经损伤、生化紊乱以及癌症治疗的不良反应。此外，癌症相关的身体虚弱和口服摄入量减少也有影响，许多癌症患者年龄较大可能也是原因之一。目前尚缺乏对便秘机制的详细了解，尤其是与疾病相关的机制，并且大多数治疗方法仍缺乏特异性。
