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Cancer constipation: are opioids really the culprit?

作者信息

Davis Mellar P

出版信息

Support Care Cancer. 2008 May;16(5):427-9. doi: 10.1007/s00520-007-0386-9. Epub 2008 Jan 15.

DOI:10.1007/s00520-007-0386-9
PMID:18196285
Abstract
摘要

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Cancer constipation: are opioids really the culprit?癌症相关性便秘：阿片类药物真的是罪魁祸首吗？
Support Care Cancer. 2008 May;16(5):427-9. doi: 10.1007/s00520-007-0386-9. Epub 2008 Jan 15.
2
Management of opioid-induced constipation.阿片类药物所致便秘的管理
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New Options in Constipation Management.便秘管理的新选择
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The use of opioids and laxatives, and incidence of constipation, in patients requiring neck-of-femur (NOF) surgery: a pilot study.股骨颈（NOF）手术患者中阿片类药物和泻药的使用情况以及便秘发生率：一项试点研究。
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Methylnaltrexone: a subcutaneous treatment for opioid-induced constipation in palliative care patients.甲基纳曲酮：姑息治疗患者阿片类药物引起便秘的皮下治疗方法。
Int J Palliat Nurs. 2009 Nov;15(11):533-40. doi: 10.12968/ijpn.2009.15.11.45492.
6
Treating constipation in palliative care: the impact of other factors aside from opioids.
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A multi-institutional study analyzing effect of prophylactic medication for prevention of opioid-induced gastrointestinal dysfunction.一项多机构研究分析了预防用药对预防阿片类药物引起的胃肠道功能障碍的效果。
Clin J Pain. 2012 Jun;28(5):373-81. doi: 10.1097/AJP.0b013e318237d626.
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[Constipation - pathophysiology, diagnostics, treatment].[便秘——病理生理学、诊断、治疗]
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Guidelines for the control of constipation in adult patients with cancer.
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引用本文的文献

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Naldemedine for the management of opioid-induced constipation in patients with cancer pain: A narrative review.纳洛酮用于癌症疼痛患者阿片类药物引起便秘的管理：一项叙述性综述。
Medicine (Baltimore). 2025 Aug 1;104(31):e43644. doi: 10.1097/MD.0000000000043644.
2
A Handheld Ultrasound Device Can Predict Constipation with Rectal Fecal Retention in a Palliative Care Setting.在姑息治疗环境中，手持式超声设备可预测伴有直肠粪便潴留的便秘。
Diagnostics (Basel). 2024 Jul 28;14(15):1626. doi: 10.3390/diagnostics14151626.
3
The Efficacy and Safety of Transcutaneous Acupoint Interferential Current Stimulation for Cancer Pain Patients With Opioid-Induced Constipation: A Prospective Randomized Controlled Study.

本文引用的文献

1
The burden of constipation on quality of life: results of a multinational survey.便秘对生活质量的影响：一项跨国调查的结果
Aliment Pharmacol Ther. 2007 Jul 15;26(2):227-36. doi: 10.1111/j.1365-2036.2007.03376.x.
2
A comparative reappraisal of the Rome II and Rome III diagnostic criteria: are we getting closer to the 'true' prevalence of irritable bowel syndrome?罗马II与罗马III诊断标准的比较性重新评估：我们是否更接近肠易激综合征的“真实”患病率？
Eur J Gastroenterol Hepatol. 2007 Jun;19(6):441-7. doi: 10.1097/MEG.0b013e32801140e2.
3
The opioid bowel syndrome: a review of pathophysiology and treatment.
经皮穴位干扰电刺激对阿片类药物所致便秘的癌症疼痛患者的疗效及安全性：一项前瞻性随机对照研究。
Integr Cancer Ther. 2018 Jun;17(2):437-443. doi: 10.1177/1534735417734910. Epub 2017 Oct 27.
4
Genetic and Non-genetic Factors Associated With Constipation in Cancer Patients Receiving Opioids.接受阿片类药物治疗的癌症患者便秘相关的遗传和非遗传因素。
Clin Transl Gastroenterol. 2015 Jun 18;6(6):e90. doi: 10.1038/ctg.2015.19.
5
[Observational and cross-sectional study of prevalence and severity of the opioid-induced bowel dysfunction].[阿片类药物所致肠道功能障碍患病率及严重程度的观察性和横断面研究]
Aten Primaria. 2014 Jan;46(1):32-9. doi: 10.1016/j.aprim.2013.08.007. Epub 2013 Dec 13.
6
A pilot study to assess the feasibility of measuring the prevalence of slow colon transit or evacuation disorder in palliative care.一项评估在姑息治疗中测量慢传输或排出障碍流行率的可行性的初步研究。
J Palliat Med. 2013 May;16(5):542-5. doi: 10.1089/jpm.2012.0379. Epub 2013 Apr 27.
7
Clinical use of oral laxatives in palliative care services in Spain.西班牙姑息治疗服务中口服缓泻药的临床应用。
Support Care Cancer. 2010 Nov;18(11):1491-4. doi: 10.1007/s00520-010-0956-0. Epub 2010 Aug 8.
阿片类药物所致肠道综合征：病理生理学与治疗综述
J Opioid Manag. 2005 Jul-Aug;1(3):153-61. doi: 10.5055/jom.2005.0035.
4
Audit of constipation in a gastroenterology referral center.胃肠病转诊中心便秘情况的审计
Dig Dis Sci. 2007 Feb;52(2):317-20. doi: 10.1007/s10620-006-9486-5. Epub 2007 Jan 9.
5
The pathogenesis of constipation.便秘的发病机制。
J Support Oncol. 2006 May;4(5):213-8.
6
Symptom evaluation in palliative medicine: patient report vs systematic assessment.姑息医学中的症状评估：患者报告与系统评估
Support Care Cancer. 2006 May;14(5):444-53. doi: 10.1007/s00520-005-0009-2. Epub 2006 Jan 10.
7
Management of opioid-induced bowel dysfunction in cancer patients.癌症患者阿片类药物引起的肠道功能障碍的管理。
Support Care Cancer. 2004 Sep;12(9):613-8. doi: 10.1007/s00520-004-0649-7.
8
Aging and intestinal motility: a review of factors that affect intestinal motility in the aged.衰老与肠道蠕动：影响老年人肠道蠕动因素的综述
Drugs Aging. 2002;19(7):515-27. doi: 10.2165/00002512-200219070-00005.
9
Gastrointestinal motility problems in the elderly patient.老年患者的胃肠动力问题
Gastroenterology. 2002 May;122(6):1688-700. doi: 10.1053/gast.2002.33566.
10
Morphine, constipation and performance status in advanced cancer patients.
Palliat Med. 1999 Mar;13(2):159-60. doi: 10.1191/026921699677653615.