Luján Galán Marcos, Pascual Mateo Carlos, Rodríguez García Nuria, García Mediero José María, Pascual Durán Tomás, Paez Borda Alvaro, Berenguer Sánchez Antonio
Servicio de Urología, Hospital Universitario de Getafe, Getafe, Madrid, España.
Arch Esp Urol. 2006 Apr;59(3):247-52. doi: 10.4321/s0004-06142006000300005.
To analyze the impact of season and weather parameters on serum PSA values in men without prostate cancer.
Retrospective study including medical records from the Spanish arm of the European Randomized Study of Screening for Prostate Cancer (ERSPC).
prostate cancer diagnosis, PSA > = 10 ng/ml, or PSA > = 3 ng/ml and/or digital rectal examination abnormalities unless a negative prostate biopsy was provided. Univariate relationships between PSA value, season and several weather parameters were assessed. A multivariate logistic regression model was used to identify independent predictors of a PSA value > = 3 ng/ml.
A total of 2,147 men entered into the study. Median age and PSA level were 57 years and 0.9 ng/ml respectively. A non-significant trend to higher PSA levels was observed during autumn and winter. Multivariate logistic regression analysis identified only maximum temperature (p < 0.001), minimum temperature (p = 0.001) and age (p < 0.001) as independent predictors of a PSA value > = 3 ng/ml. Mean age-adjusted PSA levels at maximum temperatures of < = 15 degrees C, 16-20 degrees C, 21-25 degrees C and > =26 degrees C were 1.25, 1.20, 1.17 and 1.09 ng/ml respectively.
PSA levels are slightly higher during cold weather conditions. Because of the small magnitude of this PSA increment we do not recommend to change biopsy indication based solely on climatic parameters.
分析季节和天气参数对无前列腺癌男性血清PSA值的影响。
回顾性研究，纳入欧洲前列腺癌筛查随机研究（ERSPC）西班牙分部的医疗记录。
前列腺癌诊断、PSA≥10 ng/ml、或PSA≥3 ng/ml及/或直肠指检异常（除非提供前列腺活检阴性结果）。评估PSA值、季节和若干天气参数之间的单变量关系。使用多因素逻辑回归模型确定PSA值≥3 ng/ml的独立预测因素。
共有2147名男性进入研究。中位年龄和PSA水平分别为57岁和0.9 ng/ml。在秋季和冬季观察到PSA水平有升高的非显著趋势。多因素逻辑回归分析仅确定最高温度（p<0.001）、最低温度（p = 0.001）和年龄（p<0.001）为PSA值≥3 ng/ml的独立预测因素。最高温度≤15℃、16 - 20℃、21 - 25℃和≥26℃时，年龄调整后的平均PSA水平分别为1.25、1.20、1.17和1.09 ng/ml。
寒冷天气条件下PSA水平略高。由于这种PSA升高幅度较小，我们不建议仅基于气候参数改变活检指征。
