Nair-Shalliker Visalini, Smith David P, Clements Mark, Naganathan Vasikaran, Litchfield Melisa, Waite Louise, Handelsman David, Seibel Markus J, Cumming Robert, Armstrong Bruce K
Cancer Research Division, Cancer Council New South Wales, 153 Dowling Street, Wooloomooloo, Sydney, NSW, 2011, Australia,
World J Urol. 2014 Oct;32(5):1251-7. doi: 10.1007/s00345-013-1201-5. Epub 2013 Nov 5.
We aim to determine the relationship between season, personal solar UV exposure, serum 25(OH)D and 1,25(OH)2D and serum prostate-specific antigen (PSA) levels.
Questionnaire data and blood samples were collected at baseline from participants of the Concord Health and Ageing in Men Project (n = 1,705), aged 70 and above. They were grouped as men 'free of prostate disease' for those with no record of having prostate cancer, benign prostatic hyperplasia, or prostatitis and with serum PSA levels below 20 ng/mL, and 'with prostate disease' for those with a record of either of these diseases or with serum PSA levels 20 ng/mL or above. Personal solar UV exposure (sUV) was estimated from recalled hours of outdoor exposure and weighted against ambient solar UV radiation. Sera were analysed to determine levels of PSA, 25(OH)D and 1,25(OH)2D, and analysed using multiple regression, adjusting for age, BMI and region of birth.
The association between sUV and serum PSA levels was conditional upon season (p interaction = 0.04). There was no direct association between serum PSA and 25(OH)D in both groups of men. There was a positive association between serum PSA and 1,25(OH)2D in men with prostate disease (mean = 110.6 pmol/L; p heterogeneity = 0.03), but there was no such association in men free of prostate disease (mean = 109.3 pmol/L; p heterogeneity = 0.8).
The association between PSA and sUV may only be evident at low solar UV irradiance, and this effect may be independent of serum vitamin D levels.
我们旨在确定季节、个人日光紫外线暴露、血清25(OH)D和1,25(OH)2D与血清前列腺特异性抗原（PSA）水平之间的关系。
从康科德男性健康与老龄化项目（n = 1705）的70岁及以上参与者中在基线时收集问卷数据和血液样本。对于没有前列腺癌、良性前列腺增生或前列腺炎记录且血清PSA水平低于20 ng/mL的男性，归为“无前列腺疾病”组；对于有这些疾病记录之一或血清PSA水平为20 ng/mL及以上的男性，归为“有前列腺疾病”组。根据回忆的户外暴露小时数估算个人日光紫外线暴露（sUV），并根据环境日光紫外线辐射进行加权。分析血清以确定PSA、25(OH)D和1,25(OH)2D的水平，并使用多元回归进行分析，同时调整年龄、体重指数和出生地区。
sUV与血清PSA水平之间的关联取决于季节（p交互作用 = 0.04）。两组男性中血清PSA与25(OH)D之间均无直接关联。有前列腺疾病的男性中血清PSA与1,25(OH)2D之间存在正相关（均值 = 110.6 pmol/L；p异质性 = 0.03），但无前列腺疾病的男性中不存在这种关联（均值 = 109.3 pmol/L；p异质性 = 0.8）。
PSA与sUV之间的关联可能仅在低日光紫外线辐照度时明显，且这种效应可能独立于血清维生素D水平。
