Watanabe Yoshiyuki, Watari Eiji, Matsunaga Isamu, Hiromatsu Kenji, Dascher Christopher C, Kawashima Tetsuo, Norose Yoshihiko, Shimizu Kazuo, Takahashi Hidemi, Yano Ikuya, Sugita Masahiko
Department of Microbiology and Immunology, Nippon Medical School, Tokyo 113-8602, Japan, and Department of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA.
Vaccine. 2006 Jul 17;24(29-30):5700-7. doi: 10.1016/j.vaccine.2006.04.049. Epub 2006 May 11.
The universe of antigens recognized by alphabeta T cells has recently been expanded to include not only major histocompatibility complex (MHC)-presented protein antigens but also CD1-presented lipid antigens. The significance of lipid-reactive T cells in host defense has been appreciated, using the guinea pig model of human tuberculosis. Here, we show that immunization with Mycobacterium bovis bacillus Calmette-Guerin (BCG), the commonly used anti-tuberculosis vaccine, induces activation of guinea pig cytotoxic T cells recognizing BCG lipids in the context of CD1 molecules. Further, BCG-immunized, but not mock-immunized, guinea pigs mount IgG antibody responses directed against lipoarabinomannnan, an essential cell wall lipid component of mycobacteria. These observations emphasize the ability of BCG to activate the host adaptive immunity to mycobacteria-derived lipids, which could potentially contribute to protection against tuberculosis.
最近，αβ T细胞识别的抗原范围已扩大，不仅包括主要组织相容性复合体（MHC）呈递的蛋白质抗原，还包括CD1呈递的脂质抗原。利用人类结核病的豚鼠模型，脂质反应性T细胞在宿主防御中的重要性已得到认可。在此，我们表明，用常用的抗结核疫苗卡介苗（BCG）免疫可诱导豚鼠细胞毒性T细胞活化，这些T细胞在CD1分子的背景下识别BCG脂质。此外，接种BCG而非模拟免疫的豚鼠会产生针对脂阿拉伯甘露聚糖的IgG抗体反应，脂阿拉伯甘露聚糖是分枝杆菌细胞壁的一种重要脂质成分。这些观察结果强调了BCG激活宿主对分枝杆菌衍生脂质的适应性免疫的能力，这可能有助于预防结核病。
