Kesler D J, Elmore R G, Brown E M, Garverick H A
Department of Animal Science University of Illinois Urbana, Illinois 61801 USA.
Theriogenology. 1981 Aug;16(2):207-17. doi: 10.1016/0093-691x(81)90103-5.
Dairy cows diagnosed as having ovarian cysts were assigned to receive either sterile water or 100 mug GnRH (5 cows/group). Immediately prior to treatment and three days post-treatment, ovaries were observed via paralumbar laparotomy, photographed and visible structures and ovarian size recorded. Nine to thirteen days post-treatment, ovaries were removed. Blood plasma was collected for hormone determinations prior to each surgery, 1.5 and 3.0 hours and 1, 5 and 9 days post-treatment. Although concentrations were similar between groups prior to treatment, concentrations of progesterone were higher and LH and estradiol-17beta lower for GnRH treated cows than control cows, immediately prior to ovariectomy. A layer of luteal tissue approximately 5 mm thick was present around the periphery of the cystic structure at ovariectomy in 4 of 5 GnRH treated cows, but in only one control cow. The thickness of the luteal layer around the periphery of the ovarian cysts was correlated -.82, .78 and -.63 with estradiol-17beta, progesterone and LH, respectively. In summary, response to GnRH treatment in cows with ovarian cysts appears to be characterized in most cases by luteinization of the cystic structures.
被诊断患有卵巢囊肿的奶牛被分配接受无菌水或100微克促性腺激素释放激素（GnRH）治疗（每组5头奶牛）。在治疗前及治疗后三天，通过腰旁剖腹术观察卵巢，拍照并记录可见结构和卵巢大小。治疗后9至13天，切除卵巢。在每次手术前、治疗后1.5小时和3.0小时以及1、5和9天采集血浆用于激素测定。尽管治疗前两组之间的浓度相似，但在即将进行卵巢切除术时，GnRH治疗组奶牛的孕酮浓度较高，促黄体生成素（LH）和雌二醇-17β浓度低于对照组奶牛。在接受GnRH治疗的5头奶牛中，有4头在卵巢切除时，囊肿结构周围有一层约5毫米厚的黄体组织，而对照组奶牛中只有1头有。卵巢囊肿周围黄体层的厚度与雌二醇-17β、孕酮和LH的相关性分别为-0.82、0.78和-0.63。总之，大多数情况下，患有卵巢囊肿的奶牛对GnRH治疗的反应似乎以囊肿结构的黄体化为特征。
