Morgan P M, Hutz R J, Kraus E M, Cormie J A, Dierschke D J, Bavister B D
Wiscons in Regional Primate Research Center University of Wisconsin Madison, WI 53715-1299 USA.
Theriogenology. 1987 May;27(5):769-80. doi: 10.1016/0093-691x(87)90299-8.
The purpose of this study was to determine if the ovaries and uterus of rhesus monkeys could be visualized by ultrasonography and to detect changes associated with follicular growth and ovulation. Animals were examined during 15 menstrual cycles, for an average of nine consecutive days. Ultrasonic recordings were correlated with hormonal parameters (estradiol 17beta, E(2); luteinizing hormone, LH; and progesterone, P) and laparoscopic findings. The uterus and both ovaries were observed in more than 90% of the examinations. A dominant follicle (DF) was identified during all ovulatory cycles, on average 1 d preceding the E(2) peak. The maximal diameter of the DF ranged from 3 to 7 mm. Laparoscopic examinations to determine the site of the DF confirmed ultrasonic findings in 10 of 14 cycles (P < 0.1). There was no significant difference in the size of the dominant and contralateral ovaries; however, more follicles with a diameter of 2 to 7 mm were found on the dominant ovary (P < 0.05). Two animals stimulated with exogenous gonadotropins showed a linear increase in ovarian size for 6 d prior to oocyte recovery (P < 0.05), reflecting an increase in the number of developing follicles. Ultrasonography can be used to identify the DF during spontaneous cycles in rhesus monkeys and to monitor the response of monkeys to exogenous gonadotropins.
本研究的目的是确定超声检查能否观察恒河猴的卵巢和子宫，并检测与卵泡生长和排卵相关的变化。在15个月经周期内对动物进行检查，平均连续检查9天。超声记录与激素参数（雌二醇17β、E(2)；促黄体生成素、LH；和孕酮、P）以及腹腔镜检查结果相关联。在超过90%的检查中观察到了子宫和双侧卵巢。在所有排卵周期中均识别出优势卵泡（DF），平均在E(2)峰值前1天。DF的最大直径范围为3至7毫米。用于确定DF位置的腹腔镜检查在14个周期中的10个周期中证实了超声检查结果（P < 0.1）。优势卵巢和对侧卵巢的大小没有显著差异；然而，在优势卵巢上发现了更多直径为2至7毫米的卵泡（P < 0.05）。两只用外源性促性腺激素刺激的动物在卵母细胞回收前6天卵巢大小呈线性增加（P < 0.05），这反映了发育中卵泡数量的增加。超声检查可用于识别恒河猴自发周期中的DF，并监测猴子对外源性促性腺激素的反应。
