Gibbs N M, Harrison B A
Department of Anaesthesia, Sir Charles Gairdner Hospital, Nedlands, Western Australia.
Anaesth Intensive Care. 1991 Feb;19(1):92-5. doi: 10.1177/0310057X9101900117.
The effect of two different doses of vecuronium on the heart rate and mean arterial pressure response to tracheal intubation was compared in 32 adult ASA class I patients. It was found that the higher dose of vecuronium (2.5 X ED95) produced greater depression of the evoked electromyogram (P less than 0.01), and provided better intubating conditions (P less than 0.01) than the lower dose of vecuronium (1 X ED95). However, the heart rate and the mean arterial pressure response to tracheal intubation was similar with both doses. The results indicate that, within the range of neuromuscular blockade commonly used to facilitate tracheal intubation, the depth of neuromuscular blockade per se does not affect the haemodynamic response to intubation.
在32例成年ASA I级患者中，比较了两种不同剂量维库溴铵对气管插管时心率和平均动脉压反应的影响。结果发现，较高剂量的维库溴铵（2.5倍ED95）引起的诱发肌电图抑制作用更强（P<0.01），与较低剂量的维库溴铵（1倍ED95）相比，提供了更好的插管条件（P<0.01）。然而，两种剂量下气管插管时的心率和平均动脉压反应相似。结果表明，在常用于促进气管插管的神经肌肉阻滞范围内，神经肌肉阻滞的深度本身并不影响插管时的血流动力学反应。
