Claas Frans H J, Roelen Dave L, Mulder Arend, Doxiadis Ilias I N, Oudshoorn Machteld, Heemskerk Martin
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, the Netherlands.
Hum Immunol. 2006 Jun;67(6):424-9. doi: 10.1016/j.humimm.2006.03.004. Epub 2006 Mar 30.
The immunogenicity of an individual human leukocyte antigen (HLA) class I mismatch is different for the cellular and the humoral alloimmune responses. The consequence is that the same antigen can induce a strong antibody response and no cytotoxic T lymphocyte reactivity, but the reverse can occur also. Exact knowledge of the immunogenicity of an HLA mismatch for an individual patient can lead to a strategy of tailor-made HLA mismatching if no HLA identical donor is available. Depending on the clinical situation, one should select a donor with HLA mismatches according to the humoral or cellular mismatch algorithm.
个体人类白细胞抗原（HLA）I类错配对于细胞和体液同种免疫反应的免疫原性是不同的。其结果是，相同的抗原可以诱导强烈的抗体反应而无细胞毒性T淋巴细胞反应性，但反之也可能发生。如果没有HLA完全相同的供体，准确了解个体患者HLA错配的免疫原性可导致定制HLA错配策略。根据临床情况，应根据体液或细胞错配算法选择具有HLA错配的供体。
