Suciu-Foca N, Rohowsky-Kochan C, Reed E, Haars R, Bonagura V, King D W, Reemstma K
Fed Proc. 1985 May;44(8):2483-7.
The development of antiidiotypic autoimmunity with respect to HLA alloantigens provides an attractive explanation for the phenomenon of maternal tolerance to the fetus and for the tandem selection of two antagonistic traits, major histocompatibility complex polymorphism and alloreactivity. We have demonstrated that both T and B lymphocyte responses to allogeneic HLA antigens are subjected to feedback regulation by autologous antiidiotypic immunity. Idiotypic receptors for the alloantigen expressed by T lymphocytes induce antiidiotypic antibodies that are readily detectable in serum during pregnancy, and antiidiotypic T cells that can be revealed in the autologous mixed lymphocyte culture system. Such antiidiotypic T cells and antibodies inhibit specifically the alloimmune function of autologous T cell lines. Similarly, antiidiotypic antibodies (Ab2) to HLA antibody molecules (Ab1) block the binding of the latter to the immunizing HLA antigen. The prevalence of Ab2 over Ab1 during pregnancy may explain the maternal tolerance to the fetus.
针对人类白细胞抗原（HLA）同种异体抗原的抗独特型自身免疫的发展，为母体对胎儿的耐受性现象以及主要组织相容性复合体多态性和同种异体反应性这两种拮抗性状的串联选择提供了一个有吸引力的解释。我们已经证明，T淋巴细胞和B淋巴细胞对同种异体HLA抗原的反应都受到自体抗独特型免疫的反馈调节。T淋巴细胞表达的同种异体抗原的独特型受体诱导抗独特型抗体，在怀孕期间血清中很容易检测到，以及在自体混合淋巴细胞培养系统中可以检测到的抗独特型T细胞。这种抗独特型T细胞和抗体特异性地抑制自体T细胞系的同种免疫功能。同样，针对HLA抗体分子（Ab1）的抗独特型抗体（Ab2）会阻断后者与免疫HLA抗原的结合。怀孕期间Ab2相对于Ab1的优势可能解释了母体对胎儿的耐受性。
