Polakowska R R, Eddy R L, Shows T B, Goldsmith L A
Department of Dermatology, University of Rochester, Medical Center, NY 14642.
Cytogenet Cell Genet. 1991;56(2):105-7. doi: 10.1159/000133060.
Human epidermal type I transglutaminase coexists in keratinocytes with another cross-linking enzyme, tissue type II transglutaminase. There are at least five different forms of the enzyme in mammals. Gene mapping studies allowed us to determine whether the different transglutaminases are products of the same gene or separate genes. The gene encoding factor XIII subunit a transglutaminase (F13A1) was previously assigned to human chromosome 6, p24----p25. We demonstrate using somatic cell hybrids that the human epidermal type I transglutaminase gene (gene symbol is designated TGM1) is located on human chromosome 14, providing evidence that at least two human transglutaminases are encoded by separate genes.
人表皮I型转谷氨酰胺酶与另一种交联酶——组织II型转谷氨酰胺酶共同存在于角质形成细胞中。在哺乳动物中，该酶至少有五种不同的形式。基因定位研究使我们能够确定不同的转谷氨酰胺酶是同一基因的产物还是不同基因的产物。编码因子XIII亚基a转谷氨酰胺酶（F13A1）的基因先前已定位到人类6号染色体p24----p25区域。我们利用体细胞杂种证明，人表皮I型转谷氨酰胺酶基因（基因符号为TGM1）位于人类14号染色体上，这表明至少两种人类转谷氨酰胺酶是由不同基因编码的。
