通过体细胞杂交将人类α-3-岩藻糖基转移酶的三个预期基因之一定位到11号染色体q区。
Chromosome 11q localization of one of the three expected genes for the human alpha-3-fucosyltransferases, by somatic hybridization.
作者信息
Couillin P, Mollicone R, Grisard M C, Gibaud A, Ravisé N, Feingold J, Oriol R
机构信息
CNRS, Biochimie, Faculté de Pharmacie, Châtenay-Malabry, France.
出版信息
Cytogenet Cell Genet. 1991;56(2):108-11. doi: 10.1159/000133061.
Seventy-one human x mouse hybrid cell lines were used to map the locus of a human alpha-3-fucosyltransferase to 11q. The enzyme transfers fucose onto H type 2 more efficiently than onto sialyl-N-acetyllactosamine, suggesting that it is the myeloid type of alpha-3-fucosyltransferase (Mollicone et al., 1990), which makes the 3-fucosyllactosamine epitope on polymorphonuclear cells and monocytes. This epitope is also known as CD15 (Tetteroo et al., 1987).
利用71个人类×小鼠杂交细胞系将人类α-3-岩藻糖基转移酶的基因座定位到11号染色体长臂。该酶将岩藻糖转移到H2型上比转移到唾液酸-N-乙酰乳糖胺上更有效，这表明它是髓样型α-3-岩藻糖基转移酶（莫利科内等人，1990年），可在多形核细胞和单核细胞上形成3-岩藻糖基乳糖胺表位。该表位也被称为CD15（泰特罗等人，1987年）。
Zotero 插件