Fleisch Markus C, Maxwell Christopher A, Barcellos-Hoff Mary-Helen
Life Sciences Division, 1 Cyclotron Road, MS 977-225A, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
Endocr Relat Cancer. 2006 Jun;13(2):379-400. doi: 10.1677/erc.1.01112.
Transforming growth factor beta (TGF-beta) is a ubiquitous cytokine that plays a critical role in numerous pathways regulating cellular and tissue homeostasis. TGF-beta is regulated by hormones and is a primary mediator of hormone response in uterus, prostate and mammary glands. This review will address the role of TGF-beta in regulating hormone-dependent proliferation and morphogenesis. The subversion of TGF-beta regulation during the processes of carcinogenesis, with particular emphasis on its effects on genetic stability and epithelial to mesenchymal transition, will also be examined. An understanding of the multiple and complex mechanisms of TGF-beta regulation of epithelial function, and the ultimate loss of TGF-beta function during carcinogenesis, will be critical in the design of novel therapeutic interventions for endocrine-related cancers.
转化生长因子β（TGF-β）是一种广泛存在的细胞因子，在调节细胞和组织稳态的众多途径中发挥关键作用。TGF-β受激素调控，是子宫、前列腺和乳腺中激素反应的主要介导因子。本综述将阐述TGF-β在调节激素依赖性增殖和形态发生中的作用。还将研究致癌过程中TGF-β调节的颠覆，尤其着重于其对遗传稳定性和上皮-间质转化的影响。了解TGF-β调节上皮功能的多种复杂机制以及致癌过程中TGF-β功能的最终丧失，对于设计针对内分泌相关癌症的新型治疗干预措施至关重要。
