Varmus Harold
Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Science. 2006 May 26;312(5777):1162-5. doi: 10.1126/science.1126758.
For many years, discoveries about the genetic determinants of cancer appeared to be having only minor effects on efforts to control the disease in the clinic. Following advances made over the past decade, however, a description of cancer in molecular terms seems increasingly likely to improve the ways in which human cancers are detected, classified, monitored, and (especially) treated. Achieving the medical promise of this new era in cancer research will require a deeper understanding of the biology of cancer and imaginative application of new knowledge in the clinic, as well as political, social, and cultural changes.
多年来，有关癌症遗传决定因素的发现似乎对临床控制该疾病的努力仅产生了微小影响。然而，随着过去十年取得的进展，用分子术语描述癌症似乎越来越有可能改善人类癌症的检测、分类、监测以及（尤其是）治疗方式。要实现癌症研究这一新时代的医学前景，需要更深入地了解癌症生物学，并在临床上富有想象力地应用新知识，同时还需要政治、社会和文化变革。
