Tsivgoulis Georgios, Vemmos Konstantinos, Papamichael Christos, Spengos Konstantinos, Manios Efstathios, Stamatelopoulos Kimon, Vassilopoulos Demetrios, Zakopoulos Nikolaos
Department of Neurology, University of Athens, Eginition Hospital, Athens, Greece.
Stroke. 2006 Jul;37(7):1913-6. doi: 10.1161/01.STR.0000226399.13528.0a. Epub 2006 May 25.
Increased common carotid artery intima-media thickness (CCA-IMT) has been associated with an increased risk of myocardial infarction and stroke. We investigated the relationship between CCA-IMT and recurrent stroke in a cohort of ischemic stroke patients.
High-resolution B-mode ultrasonographic measurements of the CCA-IMT were performed in a consecutive series of 238 patients hospitalized in our institution with first-ever ischemic stroke. Stroke risk factors and secondary prevention therapies were documented. Patients were followed-up prospectively and the outcome event of interest was recurrent stroke.
During a mean follow-up period of 28.9 months (range: 6 to 60 months), 27 recurrent strokes were documented. Patients who experienced recurrent cerebrovascular events had significantly (P=0.005) higher CCA-IMT values (1.01 mm, 95% CI:0.92 to 1.11 mm) than subjects who were free of stroke recurrence (0.88 mm, 95% CI:0.85 to 0.91 mm). After adjustment for baseline characteristics, risk factors and stroke subtypes and secondary prevention therapies increasing CCA-IMT was found to be an independent predictor of stroke recurrence. For each increment of 0.1 mm in CCA-IMT the probability of experiencing recurrent stroke increased by 18.0% (95% CI:2.0% to 36.0%, P=0.027).
Increased CCA-IMT values are associated with a higher risk of long-term stroke recurrence.
颈总动脉内膜中层厚度（CCA-IMT）增加与心肌梗死和中风风险增加相关。我们在一组缺血性中风患者中研究了CCA-IMT与复发性中风之间的关系。
对我院收治的238例首次发生缺血性中风的连续住院患者进行CCA-IMT的高分辨率B型超声测量。记录中风危险因素和二级预防治疗情况。对患者进行前瞻性随访，关注的结局事件是复发性中风。
在平均28.9个月（范围：6至60个月）的随访期内，记录到27例复发性中风。发生复发性脑血管事件的患者的CCA-IMT值（1.01mm，95%CI：0.92至1.11mm）显著高于（P=0.005）未发生中风复发的患者（0.88mm，95%CI：0.85至0.91mm）。在对基线特征、危险因素、中风亚型和二级预防治疗进行调整后，发现CCA-IMT增加是中风复发的独立预测因素。CCA-IMT每增加0.1mm，发生复发性中风的概率增加18.0%（95%CI：2.0%至36.0%，P=0.027）。
CCA-IMT值增加与长期中风复发风险较高相关。
