结节病患者结核菌素试验细胞浸润的组织计量学研究。
Histometric studies on cellular infiltrates of tuberculin tests in patients with sarcoidosis.
作者信息
Lowe J G, Gibbs J H, Potts R C, Stanford J L, Swanson Beck J
机构信息
Department of Dermatology, Ninewells Hospital and Medical School, Dundee.
出版信息
J Clin Pathol. 1991 Mar;44(3):219-23. doi: 10.1136/jcp.44.3.219.
The density and microanatomical location of CD4 and CD8 lymphocytes and of monocytes/macrophages at the site of a tuberculin test were measured in 13 patients with sarcoidosis, and the results were compared with those seen in a group of healthy controls. The cellular infiltrate was significantly reduced in the sarcoid subjects compared with the controls for all cell phenotypes studied; the ratio of CD4 positive:CD8 positive lymphocytes was significantly increased in the sarcoid group. Clinically negative reactions showed substantial numbers of infiltrating mononuclear cells, although not as great as in clinically apparent reactions. A clinically negative tuberculin reaction does not necessarily imply anergy to the test substance and should not be termed "negative".
对13例结节病患者结核菌素试验部位的CD4和CD8淋巴细胞以及单核细胞/巨噬细胞的密度和微观解剖位置进行了测量，并将结果与一组健康对照者的结果进行了比较。在所研究的所有细胞表型中，结节病患者的细胞浸润与对照组相比均显著减少；结节病组中CD4阳性:CD8阳性淋巴细胞的比例显著增加。临床阴性反应显示有大量浸润的单核细胞，尽管不如临床明显反应中的数量多。临床结核菌素阴性反应不一定意味着对试验物质无反应，不应称为“阴性”。
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