Nakhoul Ibrahim N, Kozuch Peter, Varma Mala
Division of Hematology-Oncology at St. Luke's-Roosevelt Hospital Center, Continuum Cancer Centers of New York, 1000 10th Avenue, Suite 11 C02, New York, NY 10019, USA.
Clin Adv Hematol Oncol. 2006 Feb;4(2):136-44, 153.
Idiopathic thrombocytopenic purpura (ITP) is defined as isolated thrombocytopenia without a clinically apparent cause. It is categorized as acute, chronic, and refractory. Its clinical presentation ranges from acute to insidious and the bleeding may vary from minimal to severe. The target platelet count with therapy is more than 30,000/microL in sedentary individuals. Since studies regarding therapies for ITP have been mostly uncontrolled case series, the treatment recommendations are largely derived from expert opinion. This review paper summarizes the data on available therapies for adult acute and chronic/refractory ITP. The therapies include splenectomy, steroids, intravenous immunoglobulin, anti-Rh(D), monoclonal antibodies, danazol, chemotherapy, plasma exchange, and others.
特发性血小板减少性紫癜（ITP）被定义为无明显临床病因的孤立性血小板减少症。它分为急性、慢性和难治性。其临床表现从急性到隐匿性不等，出血程度可从轻微到严重。对于久坐不动的个体，治疗的目标血小板计数应高于30,000/微升。由于关于ITP治疗的研究大多是无对照的病例系列，治疗建议很大程度上源于专家意见。这篇综述文章总结了成人急性和慢性/难治性ITP现有治疗方法的数据。这些治疗方法包括脾切除术、类固醇、静脉注射免疫球蛋白、抗Rh（D）、单克隆抗体、达那唑、化疗、血浆置换等。
