Wilcock C, Bailey C J
Department of Pharmaceutical Sciences, Aston University, Birmingham, UK.
J Pharm Pharmacol. 1991 Feb;43(2):120-1. doi: 10.1111/j.2042-7158.1991.tb06645.x.
New evidence that metformin increases intestinal glucose metabolism has necessitated a re-examination of the effect of metformin on intestinal glucose absorption. Normal 18 h fasted mice received an intragastric bolus of metformin 2 h before preparation of everted gut sacs from the proximal, middle and distal regions of the jejunum and ileum. Net mucosal glucose transfer from the intestinal lumen into the tissue was reduced by 15 and 28% after 50 and 250 mg kg-1 metformin, respectively (ANOVA, P less than 0.05). Net glucose transfer into the serosal fluid was reduced by 12 and 70% after 50 and 250 mg kg-1 metformin respectively (ANOVA, P less than 0.05 and P less than 0.01). The inhibitory effect of metformin on both the mucosal and serosal glucose transfer mechanisms was greatest in the middle portion of the small intestine. The results suggest that metformin decreases intestinal glucose absorption in a dose-dependent manner by effects on mucosal and serosal glucose transfer.
二甲双胍可增加肠道葡萄糖代谢的新证据，使得有必要重新审视二甲双胍对肠道葡萄糖吸收的影响。正常禁食18小时的小鼠在从空肠和回肠的近端、中部和远端制备外翻肠囊前2小时，接受一次二甲双胍胃内推注。给予50和250mg/kg-1二甲双胍后，从肠腔到组织的净黏膜葡萄糖转运分别降低了15%和28%（方差分析，P<0.05）。给予50和250mg/kg-1二甲双胍后，进入浆膜液的净葡萄糖转运分别降低了12%和70%（方差分析，P<0.05和P<0.01）。二甲双胍对黏膜和浆膜葡萄糖转运机制的抑制作用在小肠中部最大。结果表明，二甲双胍通过影响黏膜和浆膜葡萄糖转运，以剂量依赖的方式降低肠道葡萄糖吸收。
