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Int J Impot Res. 2007 Jan-Feb;19(1):110-3. doi: 10.1038/sj.ijir.3901486. Epub 2006 May 25.
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本文引用的文献

1
Interventional CT: 30 years' experience.介入性CT：30年的经验。
Eur Radiol. 2005 Nov;15 Suppl 4:D116-20. doi: 10.1007/s10406-005-0130-9.
2
Immunohistochemical distribution of cAMP- and cGMP-phosphodiesterase (PDE) isoenzymes in the human prostate.环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）磷酸二酯酶（PDE）同工酶在人前列腺中的免疫组织化学分布
Eur Urol. 2006 Apr;49(4):740-5. doi: 10.1016/j.eururo.2005.12.050. Epub 2006 Jan 18.
3
Dynamic contrast-enhanced MRI in normal and abnormal prostate tissues as defined by biopsy, MRI, and 3D MRSI.经活检、MRI和3D MRSI定义的正常及异常前列腺组织中的动态对比增强MRI。
Magn Reson Med. 2005 Feb;53(2):249-55. doi: 10.1002/mrm.20374.
4
Prostate cancer: evaluation of vascular characteristics with dynamic contrast-enhanced T1-weighted MR imaging--initial experience.前列腺癌：动态对比增强T1加权磁共振成像评估血管特征——初步经验
Radiology. 2004 Dec;233(3):709-15. doi: 10.1148/radiol.2333032098. Epub 2004 Oct 21.
5
Priapism.
Radiol Clin North Am. 2004 Mar;42(2):427-43. doi: 10.1016/j.rcl.2004.01.008.
6
A1 and A2A adenosine receptor modulation of alpha 1-adrenoceptor-mediated contractility in human cultured prostatic stromal cells.A1和A2A腺苷受体对人培养前列腺基质细胞中α1-肾上腺素受体介导的收缩性的调节作用
Br J Pharmacol. 2004 Jan;141(2):302-10. doi: 10.1038/sj.bjp.0705535.
7
Effect of sildenafil citrate on an orthotopic prostate cancer growth and metastasis model.枸橼酸西地那非对原位前列腺癌生长和转移模型的影响。
J Urol. 2003 Sep;170(3):994-7. doi: 10.1097/01.ju.0000080321.99119.df.
8
Dynamic contrast-enhanced MRI of the prostate: is this the way to proceed for characterization of prostatic carcinoma?前列腺动态对比增强磁共振成像：这是对前列腺癌进行特征描述的可行方法吗？
Eur Radiol. 2003 May;13(5):921-4. doi: 10.1007/s00330-003-1850-7.
9
Enhancement patterns of prostate cancer in dynamic MRI.前列腺癌在动态磁共振成像中的强化模式。
Eur Radiol. 2003 May;13(5):925-30. doi: 10.1007/s00330-002-1703-9. Epub 2002 Nov 14.
10
Effects of sildenafil on human penile blood vessels.
Urology. 2000 Sep 1;56(3):539-43. doi: 10.1016/s0090-4295(00)00622-1.

使用西地那非对基线和血管调节的正常前列腺血流进行半定量成像测量。

Semiquantitative imaging measurement of baseline and vasomodulated normal prostatic blood flow using sildenafil.

作者信息

Haaga J R, Exner A, Fei B, Seftel A

机构信息

Department of Radiology, University Hospitals of Cleveland, Cleveland, OH 44106, USA.

出版信息

Int J Impot Res. 2007 Jan-Feb;19(1):110-3. doi: 10.1038/sj.ijir.3901486. Epub 2006 May 25.

DOI:10.1038/sj.ijir.3901486
PMID:16728965
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3779690/
Abstract

The physiologic variability of blood flow to the prostate has not been studied until this time. We report the vasoactive effects of sildenafil and phenylephrine on blood flow of the normal prostate. Sildenafil increases prostate blood flow by approximately 75% and phenylephrine reduces the flow incrementally. Administration of these drugs with dynamic contrast-enhanced magnetic resonance imaging may improve the diagnosis of cancerous tissue because according to the literature, tumor angiogenic vessels lack the vasoactive physiologic response of the normal tissue.

摘要

直到现在，前列腺血流的生理变异性尚未得到研究。我们报告了西地那非和去氧肾上腺素对正常前列腺血流的血管活性作用。西地那非可使前列腺血流增加约75%，而去氧肾上腺素则使血流逐渐减少。使用动态对比增强磁共振成像来给予这些药物可能会改善癌组织的诊断，因为根据文献，肿瘤血管生成血管缺乏正常组织的血管活性生理反应。