Arnavaz Anouscheh, Aurich Andreas, Weissenborn Karin, Hartmann Uwe, Emrich Hinderk M, Schneider Udo
Department of Clinical Psychiatry and Psychotherapy, Medical School Hannover, 30625 Hannover, Germany.
Psychiatry Res. 2003 Apr 1;122(3):207-9. doi: 10.1016/s0925-4927(03)00018-0.
Sildenafil (Viagra) is a selective inhibitor of the cyclic guanosine monophosphate (cGMP) specific phosphodiesterase 5 (PDE5) used for the oral treatment of male erectile dysfunction due to vasodilation. However, assessment of direct effects of sildenafil on cerebral arteries is unknown. The aim of this present experiment is to measure the possible changes in blood flow velocity of the middle cerebral artery after the administration of sildenafil and a placebo. Blood-flow velocity changes of the middle cerebral artery were measured before and 1 to 2 h after the administration of the drug. Neither the intake of sildenafil nor the application of placebo resulted in any significant changes in blood flow velocity of the right middle cerebral artery. The next step for future experiments will be in vitro measurement of the diameters of the cerebral arteries under the influence of sildenafil and in vivo measurement of carbon dioxide and cerebral blood flow velocity during sexual stimulation after sildenafil intake instead of under resting conditions.
西地那非（伟哥）是一种环磷酸鸟苷（cGMP）特异性磷酸二酯酶5（PDE5）的选择性抑制剂，用于口服治疗因血管舒张引起的男性勃起功能障碍。然而，西地那非对脑动脉的直接作用尚不清楚。本实验的目的是测量服用西地那非和安慰剂后大脑中动脉血流速度的可能变化。在给药前以及给药后1至2小时测量大脑中动脉的血流速度变化。服用西地那非和应用安慰剂均未导致右侧大脑中动脉血流速度发生任何显著变化。未来实验的下一步将是在西地那非影响下对脑动脉直径进行体外测量，以及在服用西地那非后进行性刺激期间而非静息状态下对二氧化碳和脑血流速度进行体内测量。
