通过颞部激光散斑成像对完整大鼠颅骨内的脑血流进行成像。
Imaging cerebral blood flow through the intact rat skull with temporal laser speckle imaging.
作者信息
Li Pengcheng, Ni Songlin, Zhang Li, Zeng Shaoqun, Luo Qingming
机构信息
Key Laboratory of Biomedical Photonics of Ministry of Education--Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China.
出版信息
Opt Lett. 2006 Jun 15;31(12):1824-6. doi: 10.1364/ol.31.001824.
We discovered that laser speckle temporal contrast analysis (LSTCA) is able to access the two-dimensional (2D) cerebral blood flow velocity and vessel structure through the intact rat skull. It is demonstrated that LSTCA can significantly suppress the influence of the laser speckle from the stationary structure, such as the skull, and thus reveal the blood flow and morphology of blood vessels through the laser speckle images recorded from the intact rat skull.
我们发现，激光散斑时间对比度分析（LSTCA）能够透过完整的大鼠颅骨获取二维（2D）脑血流速度和血管结构。结果表明，LSTCA能够显著抑制来自静止结构（如颅骨）的激光散斑的影响，从而通过从完整大鼠颅骨记录的激光散斑图像揭示血管的血流情况和形态。
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