Woods Mark, Woessner Donald E, Sherry A Dean
Macrocyclics, 2110 Research Row, Suite 425, Dallas, TX 75235, USA.
Chem Soc Rev. 2006 Jun;35(6):500-11. doi: 10.1039/b509907m. Epub 2006 May 10.
This tutorial review examines the fundamental aspects of a new class of contrast media for MRI based upon the chemical shift saturation transfer (CEST) mechanism. Several paramagnetic versions called PARACEST agents have shown utility as responsive agents for reporting physiological or metabolic information by MRI. It is shown that basic NMR exchange theory can be used to predict how parameters such as chemical shift, bound water lifetimes, and relaxation rates can be optimized to maximize the sensitivity of PARACEST agents.
本教程综述探讨了基于化学位移饱和转移(CEST)机制的一类新型磁共振成像(MRI)造影剂的基本方面。几种称为PARACEST试剂的顺磁性版本已显示出作为通过MRI报告生理或代谢信息的响应试剂的效用。结果表明,基本的核磁共振交换理论可用于预测如何优化化学位移、结合水寿命和弛豫率等参数,以最大限度地提高PARACEST试剂的灵敏度。