基于中性多核顺磁位移试剂包封的高度位移脂质CEST试剂。
Highly shifted LIPOCEST agents based on the encapsulation of neutral polynuclear paramagnetic shift reagents.
作者信息
Terreno Enzo, Barge Alessandro, Beltrami Lorena, Cravotto Giancarlo, Castelli Daniela Delli, Fedeli Franco, Jebasingh Bhagavathsingh, Aime Silvio
机构信息
Department of Chemisry IFM and Molecular Imaging Center, University of Torino, Via P. Giuria 7, I-10125, Torino, Italy.
出版信息
Chem Commun (Camb). 2008 Feb 7(5):600-2. doi: 10.1039/b715383j. Epub 2007 Nov 26.
DOI:10.1039/b715383j
PMID:18209802
Abstract
Improved LIPOCEST MRI contrast agents with highly shifted intraliposomal water protons were prepared by entrapping neutral polynuclear Tm(III)-based paramagnetic shift reagents in phospholipidic vesicles.
摘要
通过将基于中性多核铥（III）的顺磁位移试剂包裹在磷脂囊泡中，制备了具有高度位移的脂质体内水质子的改进型LIPOCEST MRI造影剂。
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