• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

基于中性多核顺磁位移试剂包封的高度位移脂质CEST试剂。

Highly shifted LIPOCEST agents based on the encapsulation of neutral polynuclear paramagnetic shift reagents.

作者信息

Terreno Enzo, Barge Alessandro, Beltrami Lorena, Cravotto Giancarlo, Castelli Daniela Delli, Fedeli Franco, Jebasingh Bhagavathsingh, Aime Silvio

机构信息

Department of Chemisry IFM and Molecular Imaging Center, University of Torino, Via P. Giuria 7, I-10125, Torino, Italy.

出版信息

Chem Commun (Camb). 2008 Feb 7(5):600-2. doi: 10.1039/b715383j. Epub 2007 Nov 26.

DOI:10.1039/b715383j
PMID:18209802
Abstract

Improved LIPOCEST MRI contrast agents with highly shifted intraliposomal water protons were prepared by entrapping neutral polynuclear Tm(III)-based paramagnetic shift reagents in phospholipidic vesicles.

摘要

通过将基于中性多核铥（III）的顺磁位移试剂包裹在磷脂囊泡中，制备了具有高度位移的脂质体内水质子的改进型LIPOCEST MRI造影剂。

相似文献

1
Highly shifted LIPOCEST agents based on the encapsulation of neutral polynuclear paramagnetic shift reagents.基于中性多核顺磁位移试剂包封的高度位移脂质CEST试剂。
Chem Commun (Camb). 2008 Feb 7(5):600-2. doi: 10.1039/b715383j. Epub 2007 Nov 26.
2
From spherical to osmotically shrunken paramagnetic liposomes: an improved generation of LIPOCEST MRI agents with highly shifted water protons.从球形到渗透收缩的顺磁性脂质体：新一代具有高度位移水质子的LIPOCEST MRI造影剂。
Angew Chem Int Ed Engl. 2007;46(6):966-8. doi: 10.1002/anie.200604027.
3
Osmotically shrunken LIPOCEST agents: an innovative class of magnetic resonance imaging contrast media based on chemical exchange saturation transfer.渗透收缩型脂质CEST剂：一类基于化学交换饱和转移的创新型磁共振成像造影剂。
Chemistry. 2009;15(6):1440-8. doi: 10.1002/chem.200801766.
4
Gadolinium-doped LipoCEST agents: a potential novel class of dual 1H-MRI probes.钆掺杂脂质体 CEST 试剂：一类新型的双重 1H-MRI 探针。
Chem Commun (Camb). 2011 Apr 28;47(16):4667-9. doi: 10.1039/c1cc10172b. Epub 2011 Mar 15.
5
Pushing the sensitivity envelope of lanthanide-based magnetic resonance imaging (MRI) contrast agents for molecular imaging applications.推动基于镧系元素的磁共振成像（MRI）造影剂在分子成像应用中的灵敏度极限。
Acc Chem Res. 2009 Jul 21;42(7):822-31. doi: 10.1021/ar800192p.
6
The thulium complex of 1,4,7,10-tetrakis{[N-(1H-imidazol-2-yl)carbamoyl]methyl}-1,4,7,10-tetraazacyclododecane (dotami) as a ParaCEST contrast agent.1,4,7,10-四{[N-(1H-咪唑-2-基)氨基甲酰基]甲基}-1,4,7,10-四氮杂环十二烷（dotami）的铥配合物作为一种顺磁化学交换饱和转移（ParaCEST）造影剂。
Chem Biodivers. 2008 Aug;5(8):1505-1512. doi: 10.1002/cbdv.200890139.
7
Paramagnetic lanthanide complexes as PARACEST agents for medical imaging.作为用于医学成像的顺磁镧系元素配合物的PARACEST试剂
Chem Soc Rev. 2006 Jun;35(6):500-11. doi: 10.1039/b509907m. Epub 2006 May 10.
8
Organocuprates and diamagnetic copper complexes: structures and NMR spectroscopic structure elucidation in solution.有机铜酸盐和顺磁性铜配合物：溶液中的结构及核磁共振光谱结构解析
Chem Rev. 2008 Aug;108(8):3029-53. doi: 10.1021/cr800286r.
9
1H and 13C spectral assignments of an oxytocin-DTPA derivative, a ligand for potential receptor-specific MRI contrast agents.一种用于潜在受体特异性磁共振成像造影剂的配体——催产素-二乙三胺五乙酸衍生物的1H和13C光谱归属
Magn Reson Chem. 2005 Aug;43(8):654-7. doi: 10.1002/mrc.1610.
10
Synthesis and characterization of novel natural product-Gd(III) MRI contrast agent conjugates.新型天然产物-Gd(III)磁共振成像造影剂缀合物的合成与表征
Bioorg Med Chem Lett. 2008 Dec 1;18(23):6058-61. doi: 10.1016/j.bmcl.2008.10.027. Epub 2008 Oct 11.

引用本文的文献

1
Liposomal Fe(III) Macrocyclic Complexes with Hydroxypropyl Pendants as MRI Probes.具有羟丙基支链的脂质体 Fe(III)大环配合物作为 MRI 探针。
ACS Appl Bio Mater. 2021 Nov 15;4(11):7951-7960. doi: 10.1021/acsabm.1c00879. Epub 2021 Oct 15.
2
Co Complexes as Liposomal CEST Agents.钴复合物作为脂质体 CEST 试剂。
Angew Chem Int Ed Engl. 2020 Jul 13;59(29):12093-12097. doi: 10.1002/anie.202003479. Epub 2020 May 18.
3
Recent Advances in Fluorine Magnetic Resonance Imaging with Perfluorocarbon Emulsions.全氟碳乳剂在氟磁共振成像中的最新进展
Engineering (Beijing). 2015 Dec;1(4):475-489. doi: 10.15302/J-ENG-2015103. Epub 2016 Mar 16.
4
Functional nanoparticles for magnetic resonance imaging.用于磁共振成像的功能性纳米颗粒。
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2016 Nov;8(6):814-841. doi: 10.1002/wnan.1400. Epub 2016 Apr 4.
5
Development and Characterization of Novel LipoCEST Agents Based on Thermosensitive Liposomes.基于热敏脂质体的新型脂质CEST剂的研发与表征
Magn Reson Med Sci. 2016 Jul 11;15(3):324-34. doi: 10.2463/mrms.mp.2015-0039. Epub 2016 Feb 3.
6
New strategy for monitoring targeted therapy: molecular imaging.监测靶向治疗的新策略：分子成像。
Int J Nanomedicine. 2013;8:3703-13. doi: 10.2147/IJN.S51264. Epub 2013 Sep 30.
7
Advantages of macromolecular to nanosized chemical-exchange saturation transfer agents for MRI applications.大分子到纳米级化学交换饱和转移试剂在 MRI 应用中的优势。
Future Med Chem. 2010 Mar;2(3):351-66. doi: 10.4155/fmc.09.152.
8
Imaging of apoptosis in the heart with nanoparticle technology.纳米颗粒技术在心脏细胞凋亡成像中的应用。
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2011 Jan-Feb;3(1):86-99. doi: 10.1002/wnan.115.
9
CEST and PARACEST MR contrast agents.化学交换饱和转移（CEST）和PARACEST磁共振造影剂。
Acta Radiol. 2010 Oct;51(8):910-23. doi: 10.3109/02841851.2010.502126.
10
Alternatives to gadolinium-based metal chelates for magnetic resonance imaging.用于磁共振成像的钆基金属螯合物的替代物
Chem Rev. 2010 May 12;110(5):2960-3018. doi: 10.1021/cr900284a.