Misra Sanjay, Woodrum David A, Homburger Jay, Elkouri Stephane, Mandrekar Jayawant N, Barocas Victor, Glockner James F, Rajan Dheeraj K, Mukhopadhyay Debabrata
Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Cardiovasc Intervent Radiol. 2006 Jul-Aug;29(4):624-9. doi: 10.1007/s00270-005-0168-z.
The purpose of the study was to determine simultaneously the temporal changes in luminal vessel area, blood flow, and wall shear stress (WSS) in both the anastomosed artery (AA) and vein (AV) of arteriovenous polytetrafluoroethylene (PTFE) grafts. PTFE grafts were placed from the iliac artery to the ipsilateral iliac vein in 12 castrated juvenile male pigs. Contrast-enhanced magnetic resonance angiography with cine phase-contrast magnetic resonance imaging was performed. Luminal vessel area, blood flow, and WSS in the aorta, AA, AV, and inferior vena cava were determined at 3 days (D3), 7 days (D7), and 14 days (D14) after graft placement. Elastin von Gieson staining of the AV was performed. The average WSS of the AA was highest at D3 and then decreased by D7 and D14. In contrast, the average WSS and intima-to-media ratio of the AV increased from D3 to D7 and peaked by D14. Similarly, the average area of the AA was highest by D7 and began to approximate the control artery by D14. The average area of the AV had decreased to its lowest by D7. High blood flows through the AA causes a decrease in average WSS and increase in the average luminal vessel area, whereas at the AV, the average WSS and intima-to-media ratio both increase while the average luminal vessel area decreases.
本研究的目的是同时测定动静脉聚四氟乙烯（PTFE）移植物的吻合动脉（AA）和静脉（AV）的管腔血管面积、血流和壁面剪应力（WSS）的时间变化。将PTFE移植物置于12只去势幼年雄性猪的髂动脉至同侧髂静脉。采用对比增强磁共振血管造影和电影相位对比磁共振成像。在移植物植入后3天（D3）、7天（D7）和14天（D14）测定主动脉、AA、AV和下腔静脉的管腔血管面积、血流和WSS。对AV进行弹性蛋白冯·吉森染色。AA的平均WSS在D3时最高，然后在D7和D14时下降。相比之下，AV的平均WSS和内膜与中膜比值从D3到D7增加，并在D14时达到峰值。同样，AA的平均面积在D7时最高，并在D14时开始接近对照动脉。AV的平均面积在D7时降至最低。通过AA的高血流导致平均WSS降低和平均管腔血管面积增加，而在AV处，平均WSS和内膜与中膜比值均增加，而平均管腔血管面积减小。
