Hutchings Martin, Loft Annika, Hansen Mads, Ralfkiaer Elisabeth, Specht Lena
Department of Clinical Physiology and Nuclear Medicine, PET and Cyclotron Unit, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Hematol Oncol. 2006 Sep;24(3):146-50. doi: 10.1002/hon.782.
Positron emission tomography using 2-[18F]fluoro-2-deoxy-D-glucose (FDG-PET) enables quantitative analysis of metabolic activity. This study investigated standardized uptake value (SUV) levels in the different histopathological subtypes of Hodgkin lymphoma (HL). Sixty patients with newly diagnosed HL underwent staging FDG-PET/CT after lymph node biopsy. Maximum SUV in each patient (SUV(max/total)) and in each affected region or organ (SUV(max)) were recorded. Mean SUV(max/total) was 9.3 g/ml in seven nodular lymphocyte predominance (NLP) patients, 16.3 g/ml in 38 nodular sclerosis (NS) patients, 20.8 g/ml in 11 mixed cellularity (MC) patients, and 19.5 g/ml in four patients with unclassified classical HL (CHL-NOS), (ANOVA, p = 0.011). Out of 780 sites (600 lymph node regions plus 180 organs), 208 sites were found to be affected with HL. Mean SUV(max) was 8.3 g/ml in the 12 sites with NLP, 11.2 g/ml in the 147 sites affected with NS, 14.6 g/ml in the 36 sites with MC, and 13.1 g/ml in the 13 sites with CHL-NOS (ANOVA, p = 0.002). There is a significant difference in FDG/glucose uptake between the different histopathological subtypes of HL.
使用2-[18F]氟-2-脱氧-D-葡萄糖的正电子发射断层扫描（FDG-PET）能够对代谢活性进行定量分析。本研究调查了霍奇金淋巴瘤（HL）不同组织病理学亚型的标准化摄取值（SUV）水平。60例新诊断的HL患者在淋巴结活检后接受分期FDG-PET/CT检查。记录每位患者的最大SUV（SUV（max/total））以及每个受累区域或器官的最大SUV（SUV（max））。7例结节性淋巴细胞为主型（NLP）患者的平均SUV（max/total）为9.3g/ml，38例结节硬化型（NS）患者为16.3g/ml，11例混合细胞型（MC）患者为20.8g/ml，4例未分类经典型HL（CHL-NOS）患者为19.5g/ml（方差分析，p = 0.011）。在780个部位（600个淋巴结区域加180个器官）中，发现208个部位受HL影响。12个NLP部位的平均SUV（max）为8.3g/ml，147个受NS影响的部位为11.2g/ml，36个MC部位为14.6g/ml，13个CHL-NOS部位为13.1g/ml（方差分析，p = 0.002）。HL不同组织病理学亚型之间的FDG/葡萄糖摄取存在显著差异。
