Gibot Sébastien
Service de Réanimation Médicale Hôpital Central, 29 avenue du Maréchal de Lattre de Tassigny, 54035 Nancy Cedex, France.
Curr Opin Investig Drugs. 2006 May;7(5):438-42.
The triggering receptor expressed on myeloid cells (TREM)-1 is a recently identified molecule that is involved in monocytic activation and the inflammatory response. It belongs to a family related to natural killer cell receptors, and is expressed on neutrophils, mature monocytes and macrophages. The engagement of TREM-1 synergizes with the activation of several toll-like receptors in amplifying the inflammatory response mediated by microbial components. The modulation of the TREM-1 signaling pathway, by the use of small synthetic peptides derived from its extracellular domain, confers interesting survival advantages during experimental murine septic shock, even when administered late after the onset of sepsis.
髓系细胞触发受体（TREM）-1是最近发现的一种分子，参与单核细胞激活和炎症反应。它属于与自然杀伤细胞受体相关的家族，在中性粒细胞、成熟单核细胞和巨噬细胞上表达。TREM-1的激活与几种Toll样受体的激活协同作用，可放大由微生物成分介导的炎症反应。通过使用源自其细胞外结构域的小合成肽来调节TREM-1信号通路，在实验性小鼠脓毒症休克期间可带来显著的生存优势，即使在脓毒症发作后很晚给药也是如此。
