Anesti Vasiliki, Scorrano Luca
Dulbecco-Telethon Institute, Venetian Institute of Molecular Medicine, Via Orus 2, I-35129, Padova, Italy.
Biochim Biophys Acta. 2006 May-Jun;1757(5-6):692-9. doi: 10.1016/j.bbabio.2006.04.013. Epub 2006 Apr 19.
Mitochondria are crucial organelles for life and death of the cell. They are prominent players in energy conversion and integrated signaling pathways including regulation of Ca2+ signals and apoptosis. Their functional versatility is matched by their morphological plasticity and by their high mobility, allowing their transport at specialized cellular sites. This transport occurs by interactions with a variety of cytoskeletal proteins that also have the ability to influence shape and function of the organelle. A growing body of evidence suggests that mitochondria use cytoskeletal proteins as tracks for their movement; in turn, mitochondrial morphology and function is regulated via mostly uncharacterized pathways, by the cytoskeleton.
线粒体是细胞生死存亡的关键细胞器。它们在能量转换和整合信号通路（包括钙离子信号调节和细胞凋亡）中发挥着重要作用。它们功能的多样性与其形态可塑性和高移动性相匹配，使其能够在特定的细胞位点进行运输。这种运输通过与多种细胞骨架蛋白相互作用而发生，这些细胞骨架蛋白也能够影响细胞器的形状和功能。越来越多的证据表明，线粒体利用细胞骨架蛋白作为其移动的轨道；反过来，细胞骨架通过大多未知的途径调节线粒体的形态和功能。
