Leadsham Jane E, Gourlay Campbell W
Department of Biosciences, University of Kent, Canterbury, Kent, UK.
Biochim Biophys Acta. 2008 Jul;1783(7):1406-12. doi: 10.1016/j.bbamcr.2008.01.019. Epub 2008 Feb 8.
The influence of the cytoskeleton reaches into almost every aspect of eukaryotic cell function. It is a little surprise therefore that links between the regulation of the cytoskeleton and apoptosis have been found in a variety of eukaryotic systems. Studies from yeast have made a significant contribution to this new field of research and have highlighted the importance of interactions between the cytoskeleton and mitochondria in determining cell fate. In yeast both the actin and microtubular cytoskeletons have been shown to influence mitochondrial function and the commitment to apoptosis. In this review we discuss the recent advances and speculate that apoptotic mechanisms that feed off the ability of the cytoskeleton to respond to environmental signals may represent a useful mechanism to remove weak or damaged individuals from a population.
细胞骨架的影响几乎涉及真核细胞功能的方方面面。因此，在各种真核系统中发现细胞骨架调节与细胞凋亡之间的联系也就不足为奇了。酵母研究为这个新的研究领域做出了重大贡献，并突出了细胞骨架与线粒体之间的相互作用在决定细胞命运方面的重要性。在酵母中，肌动蛋白和微管细胞骨架均已显示出会影响线粒体功能以及细胞凋亡进程。在本综述中，我们讨论了最近的进展，并推测基于细胞骨架响应环境信号能力的凋亡机制可能是从群体中清除弱小或受损个体的一种有用机制。
