Fierro Brigida, Brighina Filippo, Giglia Giuseppe, Palermo Antonio, Francolini Margherita, Scalia Simona
Dipartimento di Neurologia, Oftalmologia, Otorinolaringoiatria e Psichiatria, Università di Palermo, Via G. La Loggia, 90129, Palermo, Italy.
J Neurol Sci. 2006 Sep 25;247(2):144-8. doi: 10.1016/j.jns.2006.04.006. Epub 2006 May 26.
We previously observed a relative contralateral neglect by right parietal single-pulse TMS given 150 ms after visual stimulus presentation. Here we investigated the effects of parietal paired TMS in normal subjects performing a visuospatial task.
Thirteen right-handed healthy subjects underwent a line-length judgement task during single-pulse and paired (1, 3, 5, 10 ms ISIs) TMS, delivered on the right parietal cortex 150 ms after visual stimulus.
Single pulse TMS over the right parietal cortex induced a significant rightward bias compared to the baseline condition. At 1 and 3 ms ISIs, paired-pulse TMS did not show any effect in comparison with single pulse TMS. More importantly, 5 ms ISI was able to restore baseline levels, thus inducing a significant improvement of the performance compared to single-pulse TMS and 1-3 ms ISIs.
Paired TMS seems able to modulate activity of the right posterior parietal cortex in healthy subjects performing a cognitive visuospatial task.
我们之前观察到，在视觉刺激呈现后150毫秒给予右顶叶单脉冲经颅磁刺激（TMS）时，会出现相对对侧忽视。在此，我们研究了顶叶配对TMS对执行视觉空间任务的正常受试者的影响。
13名右利手健康受试者在单脉冲和配对（1、3、5、10毫秒刺激间隔）TMS期间进行线长判断任务，在视觉刺激后150毫秒对右顶叶皮质施加TMS。
与基线条件相比，右顶叶皮质的单脉冲TMS诱发了显著的向右偏差。在1和3毫秒刺激间隔时，配对脉冲TMS与单脉冲TMS相比未显示出任何效果。更重要的是，5毫秒刺激间隔能够恢复到基线水平，因此与单脉冲TMS和1 - 3毫秒刺激间隔相比，显著改善了表现。
配对TMS似乎能够调节执行认知视觉空间任务的健康受试者右后顶叶皮质的活动。
