Rybakowski Janusz K, Wykretowicz Andrzej, Heymann-Szlachcinska Agnieszka, Wysocki Henryk
Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Biol Psychiatry. 2006 Oct 15;60(8):889-91. doi: 10.1016/j.biopsych.2006.03.025. Epub 2006 May 30.
Previous studies have suggested an association between abnormal endothelial function and depression. We therefore tested this hypothesis in patients with depression in the course of mood disorders and assessed the effect of antidepressant treatment.
Psychometric evaluation and hemodynamic and endothelial function studies using pulse wave analysis were performed on a group of 31 patients with unipolar or bipolar depression. The control group consisted of 18 healthy subjects, age- and gender-matched.
Arterial endothelial function was impaired in patients compared with that in control subjects, both during a depressive episode and when in remission after pharmacological treatment. The diagnosis, intensity of depression, and type of antidepressant drugs did not influence the results.
The impairment of endothelial function might constitute a trait marker of the biological make-up of patients with mood disorders and might contribute to the increased frequency of cardiovascular conditions observed in these patients.
先前的研究表明内皮功能异常与抑郁症之间存在关联。因此，我们在心境障碍病程中的抑郁症患者中验证了这一假设，并评估了抗抑郁治疗的效果。
对一组31例单相或双相抑郁症患者进行了心理测量评估以及使用脉搏波分析的血流动力学和内皮功能研究。对照组由18名年龄和性别匹配的健康受试者组成。
与对照组相比，患者在抑郁发作期间以及药物治疗缓解后，动脉内皮功能均受损。抑郁症的诊断、严重程度以及抗抑郁药物的类型均未影响研究结果。
内皮功能受损可能是心境障碍患者生物学构成的一个特质性标志物，并且可能导致这些患者心血管疾病发生率增加。
